TY - GEN
T1 - DESIGNING AN ACCURATE BENCHTOP CHARACTERIZATION DEVICE
T2 - 2022 Design of Medical Devices Conference, DMD 2022
AU - Liang, Ruixing
AU - Kerensky, Max
AU - Curry, Eli
AU - Mess, Griffin
AU - Thombre, Rasika
AU - Kamal, Serene
AU - Aghabaglou, Fariba
AU - Mejia, Richard
AU - Chavez, Francisco
AU - Morrison, Kyle
AU - Thakor, Nitish
AU - Theodore, Nicholas
AU - Manbachi, Amir
N1 - Publisher Copyright:
© 2022 by ASME
PY - 2022
Y1 - 2022
N2 - Focused ultrasound (FUS) is becoming widely researched for medical therapies due to its high penetration depth, spatial resolution, and affordability. Applications of FUS range from high intensity focused ultrasound (HIFU) for the ablation of cancerous tumors to low intensity focused ultrasound (LIFU) for the treatment of neurological conditions like essential tremors. A key step in developing these treatments and their corresponding FUS devices is characterizing the emitted ultrasound from the proposed transducer. However, a bottleneck exists at this verification and validation stage; current characterization techniques lack the robustness of reliably recording below a 5µm resolution. This level of accuracy is needed to adequately design devices which can target cells like astrocytes or other desired target tissues at this scale. Our Acoustic Measurement Platform for Localizing and Implementing Therapeutic Ultrasound Devices and Equipment (AMPLITUDE) is a solution which enables engineers, scientists, and clinicians to confidently characterize their equipment in a benchtop setting. It achieves this resolution by utilizing an all-in-one water conditioning unit, linear stepper motors with a theoretical step size of 1 µm and a 1% standard deviation on repetitive experiments, as well as signal processing techniques. This system can be used throughout the product timeline including prototyping, verifying efficacy, FDA testing, and routine check-ups during clinical use.
AB - Focused ultrasound (FUS) is becoming widely researched for medical therapies due to its high penetration depth, spatial resolution, and affordability. Applications of FUS range from high intensity focused ultrasound (HIFU) for the ablation of cancerous tumors to low intensity focused ultrasound (LIFU) for the treatment of neurological conditions like essential tremors. A key step in developing these treatments and their corresponding FUS devices is characterizing the emitted ultrasound from the proposed transducer. However, a bottleneck exists at this verification and validation stage; current characterization techniques lack the robustness of reliably recording below a 5µm resolution. This level of accuracy is needed to adequately design devices which can target cells like astrocytes or other desired target tissues at this scale. Our Acoustic Measurement Platform for Localizing and Implementing Therapeutic Ultrasound Devices and Equipment (AMPLITUDE) is a solution which enables engineers, scientists, and clinicians to confidently characterize their equipment in a benchtop setting. It achieves this resolution by utilizing an all-in-one water conditioning unit, linear stepper motors with a theoretical step size of 1 µm and a 1% standard deviation on repetitive experiments, as well as signal processing techniques. This system can be used throughout the product timeline including prototyping, verifying efficacy, FDA testing, and routine check-ups during clinical use.
KW - 3D Heat Map
KW - Acoustic Water Tank
KW - Focused Ultrasound
KW - Medical Device Validation
UR - http://www.scopus.com/inward/record.url?scp=85130265097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85130265097&partnerID=8YFLogxK
U2 - 10.1115/DMD2022-1046
DO - 10.1115/DMD2022-1046
M3 - Conference contribution
AN - SCOPUS:85130265097
T3 - Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022
BT - Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022
PB - American Society of Mechanical Engineers
Y2 - 11 April 2022 through 14 April 2022
ER -