Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation

Efrat Abramson, Clayton Hardman, Akira J. Shimizu, Soonmyung Hwang, Lynda D Hester, Solomon H. Snyder, Paul A. Wender, Paul M. Kim, Michael Kornberg

Research output: Contribution to journalArticlepeer-review

Abstract

Bryostatin-1, a brain-penetrant natural compound, was previously shown to attenuate neuroinflammation by targeting innate immunity but has tolerability constraints. Abramson et al. identified synthetic analogs (bryologs) that similarly modulate innate immunity, including a lead bryolog with tolerability advantages and equivalent efficacy, creating a platform for drug development in neuroinflammation.

Original languageEnglish (US)
JournalCell Chemical Biology
DOIs
StateAccepted/In press - 2021

Keywords

  • bryolog
  • bryostatin
  • EAE
  • innate immunity
  • microglia
  • multiple sclerosis
  • neuroinflammation
  • PKC
  • prostratin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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