Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

A. Udemba, G. Smith, Q. D. Nguyen, M. Kaliszczak, L. Carroll, R. Fortt, M. J. Fuchter, E. O. Aboagye

Research output: Contribution to journalArticle

Abstract

Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.

Original languageEnglish (US)
Pages (from-to)5418-5423
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number19
DOIs
StatePublished - May 21 2015

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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