Abstract
Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5418-5423 |
| Number of pages | 6 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 13 |
| Issue number | 19 |
| DOIs | |
| State | Published - May 21 2015 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Udemba, A., Smith, G., Nguyen, Q. D., Kaliszczak, M., Carroll, L., Fortt, R., Fuchter, M. J., & Aboagye, E. O. (2015). Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7. Organic and Biomolecular Chemistry, 13(19), 5418-5423. https://doi.org/10.1039/c5ob00058k