Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

A. Udemba; G. Smith; Q. D. Nguyen; M. Kaliszczak; L. Carroll; R. Fortt; M. J. Fuchter; E. O. Aboagye

doi:10.1039/c5ob00058k

Design, synthesis and initial characterisation of a radiolabelled [¹⁸F]pyrimidoindolone probe for detecting activated caspase-3/7

A. Udemba, G. Smith, Q. D. Nguyen, M. Kaliszczak, L. Carroll, R. Fortt, M. J. Fuchter, E. O. Aboagye

Research output: Contribution to journal › Article › peer-review

Abstract

Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.

Original language	English (US)
Pages (from-to)	5418-5423
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	19
DOIs	https://doi.org/10.1039/c5ob00058k
State	Published - May 21 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c5ob00058k

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Design, synthesis and initial characterisation of a radiolabelled [¹⁸F]pyrimidoindolone probe for detecting activated caspase-3/7. / Udemba, A.; Smith, G.; Nguyen, Q. D.; Kaliszczak, M.; Carroll, L.; Fortt, R.; Fuchter, M. J.; Aboagye, E. O.

In: Organic and Biomolecular Chemistry, Vol. 13, No. 19, 21.05.2015, p. 5418-5423.

Research output: Contribution to journal › Article › peer-review

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AU - Nguyen, Q. D.

AU - Kaliszczak, M.

AU - Carroll, L.

AU - Fortt, R.

AU - Fuchter, M. J.

AU - Aboagye, E. O.

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Design, synthesis and initial characterisation of a radiolabelled [¹⁸F]pyrimidoindolone probe for detecting activated caspase-3/7

Abstract

ASJC Scopus subject areas

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