Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

A. Udemba; G. Smith; Q. D. Nguyen; M. Kaliszczak; L. Carroll; R. Fortt; M. J. Fuchter; E. O. Aboagye

doi:10.1039/c5ob00058k

Design, synthesis and initial characterisation of a radiolabelled [¹⁸F]pyrimidoindolone probe for detecting activated caspase-3/7

A. Udemba, G. Smith, Q. D. Nguyen, M. Kaliszczak, L. Carroll, R. Fortt, M. J. Fuchter, E. O. Aboagye

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.

Original language	English (US)
Pages (from-to)	5418-5423
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	19
DOIs	https://doi.org/10.1039/c5ob00058k
State	Published - May 21 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1039/c5ob00058k

Cite this

@article{d9f67610e7724afa803e9232d3ddf414,

title = "Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7",

abstract = "Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.",

author = "A. Udemba and G. Smith and Nguyen, {Q. D.} and M. Kaliszczak and L. Carroll and R. Fortt and Fuchter, {M. J.} and Aboagye, {E. O.}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

month = may,

day = "21",

doi = "10.1039/c5ob00058k",

language = "English (US)",

volume = "13",

pages = "5418--5423",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "19",

}

TY - JOUR

T1 - Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

AU - Udemba, A.

AU - Smith, G.

AU - Nguyen, Q. D.

AU - Kaliszczak, M.

AU - Carroll, L.

AU - Fortt, R.

AU - Fuchter, M. J.

AU - Aboagye, E. O.

PY - 2015/5/21

Y1 - 2015/5/21

N2 - Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.

AB - Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.

UR - http://www.scopus.com/inward/record.url?scp=84929094585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929094585&partnerID=8YFLogxK

U2 - 10.1039/c5ob00058k

DO - 10.1039/c5ob00058k

M3 - Article

C2 - 25865735

AN - SCOPUS:84929094585

VL - 13

SP - 5418

EP - 5423

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 19

ER -

Design, synthesis and initial characterisation of a radiolabelled [¹⁸F]pyrimidoindolone probe for detecting activated caspase-3/7

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this