Abstract
Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management. Activation of caspase-3/7 is a key biomarker of cellular apoptosis. Herein we describe the design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography.
Original language | English (US) |
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Pages (from-to) | 5418-5423 |
Number of pages | 6 |
Journal | Organic and Biomolecular Chemistry |
Volume | 13 |
Issue number | 19 |
DOIs | |
State | Published - May 21 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry