Design, synthesis and in vitro characterization of Glucagon-Like Peptide-1 derivatives for pancreatic beta cell imaging by SPECT

Medicine & Life Sciences

• Glucagon-Like Peptide 1 74%
• Insulin-Secreting Cells 67%
• Single-Photon Emission-Computed Tomography 64%
• Peptides 40%
• Indium-113 33%
• In Vitro Techniques 27%
• Coordination Complexes 23%
• Dipeptidyl Peptidase 4 21%
• Glucagon-Like Peptide-1 Receptor 20%
• Insulinoma 19%
• Cell Line 18%
• Chelating Agents 17%
• Cricetulus 16%
• Islets of Langerhans 15%
• Radionuclide Imaging 15%
• Ovary 13%
• Metals 13%

Chemical Compounds

• Glucagon-Like Peptide 1 100%
• 1,4,7,10-tetraazacyclododecane 21%
• Acetyl 15%
• Steric Effect 15%
• Chelating Agent 15%
• Kd 11%
• Resistance 9%
• Modification 8%
• Metal 7%
• Acid 5%