Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents

Srinivas K. Kumar, Erin Hager, Catherine Pettit, Hallur Gurulingappa, Nancy E. Davidson, Saeed R. Khan

Research output: Contribution to journalArticle

Abstract

A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.

Original languageEnglish (US)
Pages (from-to)2813-2815
Number of pages3
JournalJournal of medicinal chemistry
Volume46
Issue number14
DOIs
StatePublished - Jul 3 2003

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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    Kumar, S. K., Hager, E., Pettit, C., Gurulingappa, H., Davidson, N. E., & Khan, S. R. (2003). Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents. Journal of medicinal chemistry, 46(14), 2813-2815. https://doi.org/10.1021/jm030213+