Design, synthesis and evaluation of new RDP inhibitors

Hallur Gurulingappa, Phillip Buckhaults, Srinivas K. Kumar, Kenneth W. Kinzler, Bert Vogelstein, Saeed R. Khan

Research output: Contribution to journalArticlepeer-review

Abstract

Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity.

Original languageEnglish (US)
Pages (from-to)1871-1873
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number9
DOIs
StatePublished - Feb 24 2003

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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