Design, synthesis and biological evaluation of 7-azatricyclodecanes: Analogues of cocaine

Amir P. Tamiz; Miles P. Smith; Alan P. Kozikowski

doi:10.1016/S0960-894X(99)00685-X

Design, synthesis and biological evaluation of 7-azatricyclodecanes: Analogues of cocaine

Amir P. Tamiz, Miles P. Smith, Alan P. Kozikowski

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The synthesis and biological activity of a series of azatricyclodecane analogues of cocaine are described. All compounds studied in this series exhibit nanomolar potency and good selectivity for the serotonin transporter versus the dopamine transporter.

Original language	English (US)
Pages (from-to)	297-300
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(99)00685-X
State	Published - Feb 7 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00685-X

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title = "Design, synthesis and biological evaluation of 7-azatricyclodecanes: Analogues of cocaine",

abstract = "The synthesis and biological activity of a series of azatricyclodecane analogues of cocaine are described. All compounds studied in this series exhibit nanomolar potency and good selectivity for the serotonin transporter versus the dopamine transporter.",

author = "Tamiz, {Amir P.} and Smith, {Miles P.} and Kozikowski, {Alan P.}",

note = "Funding Information: We are indebted to the NIH, National Institute on Drug Abuse (DA10458) for support of this work. ",

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AU - Smith, Miles P.

AU - Kozikowski, Alan P.

N1 - Funding Information: We are indebted to the NIH, National Institute on Drug Abuse (DA10458) for support of this work.

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AN - SCOPUS:0034615075

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Design, synthesis and biological evaluation of 7-azatricyclodecanes: Analogues of cocaine

Abstract

ASJC Scopus subject areas

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