Design, synthesis and biological evaluation of 7-azatricyclodecanes: Analogues of cocaine

Amir P. Tamiz, Miles P. Smith, Alan P. Kozikowski

Research output: Contribution to journalArticle

Abstract

The synthesis and biological activity of a series of azatricyclodecane analogues of cocaine are described. All compounds studied in this series exhibit nanomolar potency and good selectivity for the serotonin transporter versus the dopamine transporter.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number3
DOIs
StatePublished - Feb 7 2000

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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