Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

Sebastian Trousil; Laurence Carroll; Andrew Kalusa; Ola Aberg; MacIej Kaliszczak; Eric O. Aboagye

doi:10.1039/c3md00068k

Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

Sebastian Trousil, Laurence Carroll, Andrew Kalusa, Ola Aberg, MacIej Kaliszczak, Eric O. Aboagye

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.

Original language	English (US)
Pages (from-to)	693-696
Number of pages	4
Journal	MedChemComm
Volume	4
Issue number	4
DOIs	https://doi.org/10.1039/c3md00068k
State	Published - Apr 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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10.1039/c3md00068k

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title = "Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors",

abstract = "Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.",

author = "Sebastian Trousil and Laurence Carroll and Andrew Kalusa and Ola Aberg and MacIej Kaliszczak and Aboagye, {Eric O.}",

year = "2013",

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doi = "10.1039/c3md00068k",

language = "English (US)",

volume = "4",

pages = "693--696",

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T1 - Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

AU - Trousil, Sebastian

AU - Carroll, Laurence

AU - Kalusa, Andrew

AU - Aberg, Ola

AU - Kaliszczak, MacIej

AU - Aboagye, Eric O.

PY - 2013/4

Y1 - 2013/4

N2 - Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.

AB - Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.

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U2 - 10.1039/c3md00068k

DO - 10.1039/c3md00068k

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JO - MedChemComm

JF - MedChemComm

IS - 4

ER -

Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

Abstract

ASJC Scopus subject areas

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