Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

Sebastian Trousil, Laurence Carroll, Andrew Kalusa, Ola Aberg, MacIej Kaliszczak, Eric O. Aboagye

Research output: Contribution to journalArticle

Abstract

Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.

Original languageEnglish (US)
Pages (from-to)693-696
Number of pages4
JournalMedChemComm
Volume4
Issue number4
DOIs
StatePublished - Apr 2013

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Cite this