Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis

Ananda Kumar, Hunter H. Chen, Erin Long, Xiaoming Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A Monte Carlo simulation analysis of optical probe design for minimally invasive tracking of gene expression in the vasculature was performed. The simulations based on efficient light delivery for excitation of green fluorescent protein (GFP) marker revealed the possibility of using percutaneous probes and intravascular probes to detect gene expression in the vessel walls. A percutaneous probe of 5 mm diameter and an intravascular probe of 2mm diameter produced identical fluence distribution in the media-intima interface of a diseased aorta for optimal excitation of GFP. But there was a seven-fold increase in the fluence rate in the normal aorta by the intravascular probe.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages285-288
Number of pages4
Volume2002-January
ISBN (Print)078037584X
DOIs
StatePublished - 2002
EventIEEE International Symposium on Biomedical Imaging, ISBI 2002 - Washington, United States
Duration: Jul 7 2002Jul 10 2002

Other

OtherIEEE International Symposium on Biomedical Imaging, ISBI 2002
CountryUnited States
CityWashington
Period7/7/027/10/02

Fingerprint

Optical Imaging
Green Fluorescent Proteins
Gene expression
Blood Vessels
Aorta
Gene Expression
Imaging techniques
Light
Proteins
Monte Carlo simulation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Kumar, A., Chen, H. H., Long, E., & Yang, X. (2002). Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis. In Proceedings - International Symposium on Biomedical Imaging (Vol. 2002-January, pp. 285-288). [1029249] IEEE Computer Society. https://doi.org/10.1109/ISBI.2002.1029249

Design of minimally invasive optical imaging probes to track vascular gene expression : A monte carlo simulation analysis. / Kumar, Ananda; Chen, Hunter H.; Long, Erin; Yang, Xiaoming.

Proceedings - International Symposium on Biomedical Imaging. Vol. 2002-January IEEE Computer Society, 2002. p. 285-288 1029249.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kumar, A, Chen, HH, Long, E & Yang, X 2002, Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis. in Proceedings - International Symposium on Biomedical Imaging. vol. 2002-January, 1029249, IEEE Computer Society, pp. 285-288, IEEE International Symposium on Biomedical Imaging, ISBI 2002, Washington, United States, 7/7/02. https://doi.org/10.1109/ISBI.2002.1029249
Kumar A, Chen HH, Long E, Yang X. Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis. In Proceedings - International Symposium on Biomedical Imaging. Vol. 2002-January. IEEE Computer Society. 2002. p. 285-288. 1029249 https://doi.org/10.1109/ISBI.2002.1029249
Kumar, Ananda ; Chen, Hunter H. ; Long, Erin ; Yang, Xiaoming. / Design of minimally invasive optical imaging probes to track vascular gene expression : A monte carlo simulation analysis. Proceedings - International Symposium on Biomedical Imaging. Vol. 2002-January IEEE Computer Society, 2002. pp. 285-288
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