Abstract
The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. Two hundred seventy-nine patients were enrolled and randomly assigned to one of these three regimens. Patients were followed monthly for 6 months and every 3 months thereafter. Outcomes of interest included: (1) mortality; (2) retinitis progression; (3) change in retinal area affected by CMV; (4) loss of visual field; (5) loss of visual acuity; (6) quality of life; and (7) treatment side effects.
Original language | English (US) |
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Pages (from-to) | 69-71 |
Number of pages | 3 |
Journal | Antiviral Research |
Volume | 29 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1996 |
Keywords
- AIDS
- Clinical trial
- Combination antiviral therapy
- Cytomegalovirus retinitis
- Foscarnet
- Ganciclovir
ASJC Scopus subject areas
- Pharmacology
- Virology