The purpose of this study is to develop an alternate in-air input device which is intended to make interaction with computers easier for amputees. This paper proposes the design and utility of accelerometer controlled Myoelectric Human Computer Interface (HCI). This device can function as a PC mouse. The two dimensional position control of the mouse cursor is done by an accelerometer-based method. The left click and right click and other extra functions of this device are controlled by the Electromyographic (EMG) signals. Artificial Neural Networks (ANNs) are used to decode the intended movements during run-time. ANN is a pattern recognition based classification. An amputee can control it using phantom wrist gestures or finger movements.