Design of a novel pinhole collimator system for SPECT imaging of small animals with different sizes

Seng Peng Mok, Yuchuan Wang, Benjamin M.W. Tsui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study aims to develop a novel pinhole collimator system for high resolution and detection efficiency imaging of mice, rats and rabbits using a 3-head SPECT camera (Philips IRIX). Utilizing the entire camera by a single pinhole (SPH) collimator with a larger collimator length (CL) and magnification offers higher spatial resolution, while using a multi-pinhole (MPH) collimator increases the detection efficiency, provided that a shorter CL with less magnification is used with minimum multiplexing and loss of resolution. Optimum imaging of different sized animals also requires adjustable CL. The proposed collimator system consists of a base of 14cm and two cones with heights of 3.5cm and 11cm. They can be assembled into a SPH collimator with a CL of 25cm, or two MPH collimators with CLs of 17.5cm and 14cm that contain changeable pinhole patterns. Resolution and detection efficiency of this system were computed using theoretical predictions and Monte Carlo simulations. The determined FWHMs of the point spread functions for imaging mice, rats and rabbits were 1.14mm, 1.27mm and 1.69mm, respectively for a SPH collimator with 1mm aperture size. The detection efficiency ratio of a 7-pinhole collimator with CL of 17.5cm and the SPH collimator was 6:1 at a point-to-aperture distance of 3.8cm. Our results demonstrate that the proposed collimator system allows flexible SPH and MPH SPECT imaging of different sized small animals while achieving high resolution and detection efficiency.

Original languageEnglish (US)
Title of host publication2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Pages2649-2652
Number of pages4
DOIs
StatePublished - Dec 1 2005
EventNuclear Science Symposium Conference Record, 2005 IEEE - , Puerto Rico
Duration: Oct 23 2005Oct 29 2005

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume5
ISSN (Print)1095-7863

Other

OtherNuclear Science Symposium Conference Record, 2005 IEEE
CountryPuerto Rico
Period10/23/0510/29/05

Keywords

  • MicroSPECT
  • Monte Carlo simulation
  • Multi-pinhole
  • Single pinhole
  • Small animal imaging

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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