Design of a Gd-DOTA-phthalocyanine conjugate combining MRI contrast imaging and photosensitization properties as a potential molecular theranostic

Duygu Aydin Tekdaş, Ruslan Garifullin, Berna Şentürk, Yunus Zorlu, Umut Gundogdu, Ergin Atalar, Ayse B. Tekinay, Alexander A. Chernonosov, Yusuf Yerli, Fabienne Dumoulin, Mustafa O. Guler, Vefa Ahsen, Ayşe Gül Gürek

Research output: Contribution to journalArticlepeer-review

Abstract

The design and synthesis of a phthalocyanine - Gd-DOTA conjugate is presented to open the way to novel molecular theranostics, combining the properties of MRI contrast imaging with photodynamic therapy. The rational design of the conjugate integrates isomeric purity of the phthalocyanine core substitution, suitable biocompatibility with the use of polyoxo water-solubilizing substituents, and a convergent synthetic strategy ended by the use of click chemistry to graft the Gd-DOTA moiety to the phthalocyanine. Photophysical and photochemical properties, contrast imaging experiments and preliminary in vitro investigations proved that such a combination is relevant and lead to a new type of potential theranostic agent.

Original languageEnglish (US)
Pages (from-to)1376-1386
Number of pages11
JournalPhotochemistry and Photobiology
Volume90
Issue number6
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Biochemistry
  • Medicine(all)

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