Design of a compartmentalized shotgun assembler for the human genome

Daniel H. Huson, Knut Reinert, Saul A. Kravitz, Karin A. Remington, Art L. Delcher, Ian M. Dew, Mike Flanigan, Aaron L. Halpern, Zhongwu Lai, Clark M. Mobarry, Granger G. Sutton, Eugene W. Myers

Research output: Contribution to journalArticlepeer-review

Abstract

Two different strategies for determining the human genome are currently being pursued: one is the "clone-by-clone" approach, employed by the publicly funded project, and the other is the "whole genome shotgun assembler" approach, favored by researchers at Celera Genomics. An interim strategy employed at Celera, called compartmentalized shotgun assembly, makes use of preliminary data produced by both approaches. In this paper we describe the design, implementation and operation of the "compartmentalized shotgun assembler".

Original languageEnglish (US)
Pages (from-to)S132-S139
JournalBioinformatics
Volume17
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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