Design, methods, and rationale in the Hypertension Prevention Trial

C. L. Meinert, N. O. Borhani, H. G. Langford

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The Hypertension Prevention Trial (HPT) was a randomized, controlled, multicenter (four clinics, four resource centers) trial designed to test the feasibility of achieving and sustaining dietary changes in the intake of calories, sodium, and potassium and to assess the effect of those changes on blood pressure in a normotensive population. The trial involved 841 men and women (plus a test cohort of 78) who, at the first baseline (BL) examination, were in the age range of 25-49 years and had diastolic blood pressure (DBP) ≥76 but <100 mm Hg (average of two readings), and at the examination prior to randomization (BL 2) had DBP ≥78 but <90 mm Hg (also averaged). Participants were randomly assigned to a control treatment group (no dietary counseling) or to one of four dietary treatment groups involving counseling designed to reduce calorie intake, reduce sodium intake, reduce sodium and calorie intake, and reduce sodium and increase potassium intake. Dietary counseling was provided primarily in group settings and was aimed at changing participants' shopping, cooking, and eating habits related to a designated treatment assignment. The effect of dietary counseling was measured through changes in urinary excretion of sodium and potassium, changes in body weight, and changes in reported food intake based on 24-hour food records. Blood pressure changes during the 3-year course of followup were based on measurements taken at 6-month intervals from enrollment using a random-zero sphygmomanometer. This chapter provides a general description of the design and methods of the HPT and the underlying rationale for decisions affecting the design.

Original languageEnglish (US)
Title of host publicationControlled Clinical Trials
Pages1S-29S
Volume10
Edition3 SUPPL.
DOIs
StatePublished - Jan 1 1989

Keywords

  • Behavior modification
  • Blood pressure
  • Calorie restricted diet
  • Clinical trial
  • Diet therapy
  • Dietary trial
  • Hypertension
  • Hypertension trial
  • Intervention trial
  • Potassium increased diet
  • Primary prevention trial
  • Sodium restricted diet
  • Weight reduction

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Meinert, C. L., Borhani, N. O., & Langford, H. G. (1989). Design, methods, and rationale in the Hypertension Prevention Trial. In Controlled Clinical Trials (3 SUPPL. ed., Vol. 10, pp. 1S-29S) https://doi.org/10.1016/0197-2456(89)90040-8