Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1

James C. Barrow, Kenneth E. Rittle, Phung L. Ngo, Harold G. Selnick, Samuel L. Graham, Steven M. Pitzenberger, Georgia B. McGaughey, Dennis Colussi, Ming Tain Lai, Qian Huang, Katherine Tugusheva, Amy S. Espeseth, Adam J. Simon, Sanjeev K. Munshi, Joseph P. Vacca