Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

Suresh K. Tipparaju, Sipak Joyasawal, Sara Forrester, Debbie C. Mulhearn, Scott Pegan, Michael E. Johnson, Andrew D. Mesecar, Alan P. Kozikowski

Research output: Contribution to journalArticle

Abstract

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.

Original languageEnglish (US)
Pages (from-to)3565-3569
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number12
DOIs
StatePublished - Jun 15 2008

Keywords

  • Anthrax

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Tipparaju, S. K., Joyasawal, S., Forrester, S., Mulhearn, D. C., Pegan, S., Johnson, M. E., Mesecar, A. D., & Kozikowski, A. P. (2008). Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase. Bioorganic and Medicinal Chemistry Letters, 18(12), 3565-3569. https://doi.org/10.1016/j.bmcl.2008.05.004