TY - GEN
T1 - Design and simulation of patient-specific tissue-engineered bifurcated right ventricle-pulmonary artery grafts using computational fluid dynamics
AU - Aslan, Seda
AU - Halperin, Henry
AU - Olivieri, Laura
AU - Hibino, Narutoshi
AU - Krieger, Axel
AU - Loke, Yue Hin
AU - Mass, Paige
AU - Nelson, Kevin
AU - Yeung, Enoch
AU - Johnson, Jed
AU - Opfermann, Justin
AU - Matsushita, Hiroshi
AU - Inoue, Takahiro
N1 - Funding Information:
This work is supported by the National Institutes of Health under award numbers R01HL143468 and R21HD090671. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2019 IEEE.
PY - 2019/10
Y1 - 2019/10
N2 - Patient-specific biodegradable grafts target to enhance surgical repairs of complex congenital heart defects (CHD). This study reports the design, simulation, and creation of bifurcated right ventricle-pulmonary artery (RVPA) conduit grafts for patients with CHD. The original right ventricle outflow tract and RVPA conduit-anatomies of two patients (n=2) who previously underwent Rastelli type surgical repair for their CHD were created using medical image segmentation software based on magnetic resonance imaging data. The pulsatile RVPA flow was simulated utilizing computational fluid dynamics (CFD) to calculate important hemodynamic parameters. The re-designed RVPA geometries for the patients were created by varying the radius and angle of the pulmonary artery bifurcation. The wall shear stress and power loss results of the re-designed RVPA models were compared to identify the best performing graft. The hemodynamic results demonstrated that the designed optimized grafts outperformed the original grafts. To test the feasibility of designed grafts in vivo, the bifurcated RVPA conduit of a pig was manufactured using a 3D printed mandrel and electrospinning technique before the implantation. The implanted graft allowed new tissue formation within weeks. The results of our study and simulations provide an insight into the creation of optimal performing tissue-engineered bifurcated grafts for the patients with CHD in the surgical planning process. Integration of flow simulations to support design and electrospinning technique to manufacture patient-specific biodegradable grafts has the potential to improve surgical outcomes in CHD.
AB - Patient-specific biodegradable grafts target to enhance surgical repairs of complex congenital heart defects (CHD). This study reports the design, simulation, and creation of bifurcated right ventricle-pulmonary artery (RVPA) conduit grafts for patients with CHD. The original right ventricle outflow tract and RVPA conduit-anatomies of two patients (n=2) who previously underwent Rastelli type surgical repair for their CHD were created using medical image segmentation software based on magnetic resonance imaging data. The pulsatile RVPA flow was simulated utilizing computational fluid dynamics (CFD) to calculate important hemodynamic parameters. The re-designed RVPA geometries for the patients were created by varying the radius and angle of the pulmonary artery bifurcation. The wall shear stress and power loss results of the re-designed RVPA models were compared to identify the best performing graft. The hemodynamic results demonstrated that the designed optimized grafts outperformed the original grafts. To test the feasibility of designed grafts in vivo, the bifurcated RVPA conduit of a pig was manufactured using a 3D printed mandrel and electrospinning technique before the implantation. The implanted graft allowed new tissue formation within weeks. The results of our study and simulations provide an insight into the creation of optimal performing tissue-engineered bifurcated grafts for the patients with CHD in the surgical planning process. Integration of flow simulations to support design and electrospinning technique to manufacture patient-specific biodegradable grafts has the potential to improve surgical outcomes in CHD.
KW - 3D printing
KW - Computational Fluid Dynamics
KW - Patient-specific Vascular Graft
KW - Tissue engineering
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UR - http://www.scopus.com/inward/citedby.url?scp=85078006755&partnerID=8YFLogxK
U2 - 10.1109/BIBE.2019.00188
DO - 10.1109/BIBE.2019.00188
M3 - Conference contribution
AN - SCOPUS:85078006755
T3 - Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
SP - 1012
EP - 1018
BT - Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
Y2 - 28 October 2019 through 30 October 2019
ER -