Design and simulation of patient-specific tissue-engineered bifurcated right ventricle-pulmonary artery grafts using computational fluid dynamics

Seda Aslan, Henry Halperin, Laura Olivieri, Narutoshi Hibino, Axel Krieger, Yue Hin Loke, Paige Mass, Kevin Nelson, Enoch Yeung, Jed Johnson, Justin Opfermann, Hiroshi Matsushita, Takahiro Inoue

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Patient-specific biodegradable grafts target to enhance surgical repairs of complex congenital heart defects (CHD). This study reports the design, simulation, and creation of bifurcated right ventricle-pulmonary artery (RVPA) conduit grafts for patients with CHD. The original right ventricle outflow tract and RVPA conduit-anatomies of two patients (n=2) who previously underwent Rastelli type surgical repair for their CHD were created using medical image segmentation software based on magnetic resonance imaging data. The pulsatile RVPA flow was simulated utilizing computational fluid dynamics (CFD) to calculate important hemodynamic parameters. The re-designed RVPA geometries for the patients were created by varying the radius and angle of the pulmonary artery bifurcation. The wall shear stress and power loss results of the re-designed RVPA models were compared to identify the best performing graft. The hemodynamic results demonstrated that the designed optimized grafts outperformed the original grafts. To test the feasibility of designed grafts in vivo, the bifurcated RVPA conduit of a pig was manufactured using a 3D printed mandrel and electrospinning technique before the implantation. The implanted graft allowed new tissue formation within weeks. The results of our study and simulations provide an insight into the creation of optimal performing tissue-engineered bifurcated grafts for the patients with CHD in the surgical planning process. Integration of flow simulations to support design and electrospinning technique to manufacture patient-specific biodegradable grafts has the potential to improve surgical outcomes in CHD.

Original languageEnglish (US)
Title of host publicationProceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1012-1018
Number of pages7
ISBN (Electronic)9781728146171
DOIs
StatePublished - Oct 2019
Event19th International Conference on Bioinformatics and Bioengineering, BIBE 2019 - Athens, Greece
Duration: Oct 28 2019Oct 30 2019

Publication series

NameProceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019

Conference

Conference19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
CountryGreece
CityAthens
Period10/28/1910/30/19

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Keywords

  • 3D printing
  • Computational Fluid Dynamics
  • Patient-specific Vascular Graft
  • Tissue engineering

ASJC Scopus subject areas

  • Information Systems
  • Biomedical Engineering
  • Health Informatics

Cite this

Aslan, S., Halperin, H., Olivieri, L., Hibino, N., Krieger, A., Loke, Y. H., Mass, P., Nelson, K., Yeung, E., Johnson, J., Opfermann, J., Matsushita, H., & Inoue, T. (2019). Design and simulation of patient-specific tissue-engineered bifurcated right ventricle-pulmonary artery grafts using computational fluid dynamics. In Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019 (pp. 1012-1018). [8941633] (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBE.2019.00188