Design and performance of a multichannel vestibular prosthesis that restores semicircular canal sensation in rhesus monkey

Bryce Chiang, Gene Y. Fridman, Chenkai Dai, Mehdi A. Rahman, Charles C. Della Santina

Research output: Contribution to journalArticlepeer-review

Abstract

In normal individuals, the vestibular labyrinths sense head movement and mediate reflexes that maintain stable gaze and posture. Bilateral loss of vestibular sensation causes chronic disequilibrium, oscillopsia, and postural instability. We describe a new multichannel vestibular prosthesis (MVP) intended to restore modulation of vestibular nerve activity with head rotation. The device comprises motion sensors to measure rotation and gravitoinertial acceleration, a microcontroller to calculate pulse timing, and stimulator units that deliver constant-current pulses to microelectrodes implanted in the labyrinth. This new MVP incorporates many improvements over previous prototypes, including a 50% decrease in implant size, a 50% decrease in power consumption, a new microelectrode array design meant to simplify implantation and reliably achieve selective nerve-electrode coupling, multiple current sources conferring ability to simultaneously stimulate on multiple electrodes, and circuitry for in vivo measurement of electrode impedances. We demonstrate the performance of this device through in vitro bench-top characterization and in vivo physiological experiments with a rhesus macaque monkey.

Original languageEnglish (US)
Article number5986721
Pages (from-to)588-598
Number of pages11
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume19
Issue number5
DOIs
StatePublished - Oct 2011

Keywords

  • Neural engineering
  • semicircular canal implant
  • sensory neural prosthesis

ASJC Scopus subject areas

  • Internal Medicine
  • Neuroscience(all)
  • Biomedical Engineering

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