TY - JOUR
T1 - Design and development of a high resolution animal SPECT scanner dedicated for rat and mouse imaging
AU - Sajedi, Salar
AU - Zeraatkar, Navid
AU - Moji, Vahideh
AU - Farahani, Mohammad Hossein
AU - Sarkar, Saeed
AU - Arabi, Hossein
AU - Teymoorian, Behnoosh
AU - Ghafarian, Pardis
AU - Rahmim, Arman
AU - Reza Ay, Mohammad
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/3/21
Y1 - 2014/3/21
N2 - A dedicated small-animal SPECT system, HiReSPECT, was designed and developed to provide a high resolution molecular imaging modality in response to growing research demands. HiReSPECT is a dual-head system mounted on a rotating gantry. The detection system is based on pixelated CsI(Na) scintillator crystals coupled to two Hamamatsu H8500 Position Sensitive Photomultiplier Tubes in each head. Also, a high resolution parallel-hole collimator is applied to every head. The dimensions of each head are 50 mm×100 mm, enabling sufficient transaxial and axial fields-of-view (TFOV and AFOV), respectively, for coverage of the entire mouse in single-bed position imaging. However, a 50 mm TFOV is not sufficient for transaxial coverage of rats. To address this, each head can be rotated by 90 degrees in order to align the larger dimension of the heads with the short body axis, allowing tomographic data acquisition for rats. An innovative non-linear recursive filter was used for signal processing/detection. Resolution recovery was also embedded in the modified Maximum-Likelihood Expectation Maximization (MLEM) image reconstruction code to compensate for Collimator-Detector Response (CDR). Moreover, an innovative interpolation algorithm was developed to speed up the reconstruction code. The planar spatial resolution at the head surface and the image spatial resolutions were 1.7 mm and 1.2-1.6 mm, respectively. The measurements followed by post-processing showed that the observed count rate at 20% count loss is about 42 kcps. The system sensitivity at the collimator surface for heads 1 and 2 were 1.32 cps/μCi and 1.25 cps/μCi, respectively. The corresponding values were 1.18 cps/μCi and 1.02 cps/μCi at 8 cm distance from the collimator surfaces. In addition, whole-body scans of mice demonstrated appropriate imaging capability of the HiReSPECT.
AB - A dedicated small-animal SPECT system, HiReSPECT, was designed and developed to provide a high resolution molecular imaging modality in response to growing research demands. HiReSPECT is a dual-head system mounted on a rotating gantry. The detection system is based on pixelated CsI(Na) scintillator crystals coupled to two Hamamatsu H8500 Position Sensitive Photomultiplier Tubes in each head. Also, a high resolution parallel-hole collimator is applied to every head. The dimensions of each head are 50 mm×100 mm, enabling sufficient transaxial and axial fields-of-view (TFOV and AFOV), respectively, for coverage of the entire mouse in single-bed position imaging. However, a 50 mm TFOV is not sufficient for transaxial coverage of rats. To address this, each head can be rotated by 90 degrees in order to align the larger dimension of the heads with the short body axis, allowing tomographic data acquisition for rats. An innovative non-linear recursive filter was used for signal processing/detection. Resolution recovery was also embedded in the modified Maximum-Likelihood Expectation Maximization (MLEM) image reconstruction code to compensate for Collimator-Detector Response (CDR). Moreover, an innovative interpolation algorithm was developed to speed up the reconstruction code. The planar spatial resolution at the head surface and the image spatial resolutions were 1.7 mm and 1.2-1.6 mm, respectively. The measurements followed by post-processing showed that the observed count rate at 20% count loss is about 42 kcps. The system sensitivity at the collimator surface for heads 1 and 2 were 1.32 cps/μCi and 1.25 cps/μCi, respectively. The corresponding values were 1.18 cps/μCi and 1.02 cps/μCi at 8 cm distance from the collimator surfaces. In addition, whole-body scans of mice demonstrated appropriate imaging capability of the HiReSPECT.
KW - HiReSPECT
KW - Instrumentation
KW - SPECT
KW - Small animal imaging
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U2 - 10.1016/j.nima.2014.01.001
DO - 10.1016/j.nima.2014.01.001
M3 - Article
AN - SCOPUS:84893199953
SN - 0168-9002
VL - 741
SP - 169
EP - 176
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
ER -