Design and assembly of supramolecular dual-modality nanoprobes

Shuang Liu, Pengcheng Zhang, Sangeeta Ray Banerjee, Jiadi Xu, Martin G. Pomper, Honggang Cui

Research output: Contribution to journalArticlepeer-review

Abstract

We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nanoprobes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.

Original languageEnglish (US)
Pages (from-to)9462-9466
Number of pages5
JournalNanoscale
Volume7
Issue number21
DOIs
StatePublished - Jun 7 2015

ASJC Scopus subject areas

  • Materials Science(all)

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