Design and assembly of supramolecular dual-modality nanoprobes

Shuang Liu; Pengcheng Zhang; Sangeeta Ray Banerjee; Jiadi Xu; Martin G. Pomper; Honggang Cui

doi:10.1039/c5nr01518a

Design and assembly of supramolecular dual-modality nanoprobes

Shuang Liu, Pengcheng Zhang, Sangeeta Ray Banerjee, Jiadi Xu, Martin G. Pomper, Honggang Cui

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nanoprobes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.

Original language	English (US)
Pages (from-to)	9462-9466
Number of pages	5
Journal	Nanoscale
Volume	7
Issue number	21
DOIs	https://doi.org/10.1039/c5nr01518a
State	Published - Jun 7 2015

ASJC Scopus subject areas

Materials Science(all)

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title = "Design and assembly of supramolecular dual-modality nanoprobes",

abstract = "We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nanoprobes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.",

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AU - Liu, Shuang

AU - Zhang, Pengcheng

AU - Ray Banerjee, Sangeeta

AU - Xu, Jiadi

AU - Pomper, Martin G.

AU - Cui, Honggang

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2015/6/7

Y1 - 2015/6/7

N2 - We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nanoprobes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.

AB - We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nanoprobes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.

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Design and assembly of supramolecular dual-modality nanoprobes

Abstract

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