Design and analysis issues in pathways

C. E. Davis, S. Hunsberger, D. Murray, B. Skipper, B. Caballero, L. Stephenson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Pathways is a school based study designed to determine if a culturally appropriate intervention involving physical activity, food service, classroom curriculum and family involvement will result in a lower percent body fat (PBF) in American Indian children in intervention schools at the end of a three year period. Forty elementary schools from six tribes will be randomly assigned to receive the intervention or serve as controls. With 80% power, the study will be able to detect a difference in mean PBF of approximately 3%. Randomization will be stratified by field center and baseline BMI. Data analysis will use the mixed linear model with school as a random effect and intervention and baseline PBF as fixed effects. Imputation of missing values will allow for an intention to treat analysis. Issues considered in denning the intervention design included: school size, anticipated compliance, contamination, and assumptions regarding missing data.

Original languageEnglish (US)
Pages (from-to)A815
JournalFASEB Journal
Issue number3
StatePublished - Dec 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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