Desferrioxamine ameliorates retinal photic injury in albino rats

Zi Liang Li; Sheridan Lam And; Mark O.M. Tso

doi:10.3109/02713689109001741

Desferrioxamine ameliorates retinal photic injury in albino rats

Zi Liang Li, Sheridan Lam And, Mark O.M. Tso

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Albino rats were given intraperitoneal desferrioxamine before exposure to intense fluorescent light. Morphometric and morphologic studies of the retina indicated that there was better preservation of photoreceptor nuclei and fewer subretinal macrophages in rats treated with desferrioxamine than in the control rats. The results of the study imply that iron and hydroxyl radicals may be important mediators in photic retinal injury.

Original language	English (US)
Pages (from-to)	133-144
Number of pages	12
Journal	Current Eye Research
Volume	10
Issue number	2
DOIs	https://doi.org/10.3109/02713689109001741
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.3109/02713689109001741

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title = "Desferrioxamine ameliorates retinal photic injury in albino rats",

abstract = "Albino rats were given intraperitoneal desferrioxamine before exposure to intense fluorescent light. Morphometric and morphologic studies of the retina indicated that there was better preservation of photoreceptor nuclei and fewer subretinal macrophages in rats treated with desferrioxamine than in the control rats. The results of the study imply that iron and hydroxyl radicals may be important mediators in photic retinal injury.",

author = "Li, {Zi Liang} and And, {Sheridan Lam} and Tso, {Mark O.M.}",

note = "Funding Information: Supported in part by Core Grant EY1792, Public Health Service Grant EY1903, and EY6761 from the National Institutes of Health, Bethesda, MD, and by a Senior Investigator Award (Dr. Tso) from Research to Prevent Blindness, Inc., New York City.",

year = "1991",

doi = "10.3109/02713689109001741",

language = "English (US)",

volume = "10",

pages = "133--144",

journal = "Current Eye Research",

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T1 - Desferrioxamine ameliorates retinal photic injury in albino rats

AU - Li, Zi Liang

AU - And, Sheridan Lam

AU - Tso, Mark O.M.

N1 - Funding Information: Supported in part by Core Grant EY1792, Public Health Service Grant EY1903, and EY6761 from the National Institutes of Health, Bethesda, MD, and by a Senior Investigator Award (Dr. Tso) from Research to Prevent Blindness, Inc., New York City.

PY - 1991

Y1 - 1991

N2 - Albino rats were given intraperitoneal desferrioxamine before exposure to intense fluorescent light. Morphometric and morphologic studies of the retina indicated that there was better preservation of photoreceptor nuclei and fewer subretinal macrophages in rats treated with desferrioxamine than in the control rats. The results of the study imply that iron and hydroxyl radicals may be important mediators in photic retinal injury.

AB - Albino rats were given intraperitoneal desferrioxamine before exposure to intense fluorescent light. Morphometric and morphologic studies of the retina indicated that there was better preservation of photoreceptor nuclei and fewer subretinal macrophages in rats treated with desferrioxamine than in the control rats. The results of the study imply that iron and hydroxyl radicals may be important mediators in photic retinal injury.

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Desferrioxamine ameliorates retinal photic injury in albino rats

Abstract

ASJC Scopus subject areas

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