Abstract
P2X receptors are ion channels gated by extracellular ATP. We report here cloning of a P2X2 receptor splice variant (P2X2-2) carrying a 207 bp deletion in the intracellular C-terminus and the analysis of the corresponding genomic structure of the P2X2 gene. P2X2-2 is as highly expressed as the original P2X2 sequence in various tissues. ATP-activated currents mediated by heterologous expressed P2X2 or P2X2-2 receptors showed significant differences in desensitization time constants and steady-state currents in the continuous presence of ATP. These results imply functional differences between cells differentially expressing these P2X2 isoforms.
Original language | English (US) |
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Pages (from-to) | 294-298 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 404 |
Issue number | 2-3 |
DOIs | |
State | Published - Mar 10 1997 |
Externally published | Yes |
Keywords
- Alternative splicing
- Desensitization
- Genomic sequence
- P2X receptor
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology