Dermatomyositis and polymyositis: Clinical presentation, autoantibodies, and pathogenesis

Andrew L. Mammen

Research output: Contribution to journalArticlepeer-review

Abstract

Dermatomyositis (DM) and polymyositis (PM) are autoimmune myopathies characterized clinically by proximal muscle weakness, muscle inflammation, extramuscular manifestations, and frequently, the presence of autoantibodies. Although there is some overlap, DM and PM are separate diseases with different pathophysiological mechanisms. Furthermore, unique clinical phenotypes are associated with each of the myositis-specific autoantibodies (MSAs) associated with these disorders. This review will focus on the clinical features, pathology, and immunogenetics of PM and DM with an emphasis on the importance of autoantibodies in defining unique phenotypes and, perhaps, as clues to help elucidate the mechanisms of disease.

Original languageEnglish (US)
Pages (from-to)134-153
Number of pages20
JournalAnnals of the New York Academy of Sciences
Volume1184
DOIs
StatePublished - Jan 2010

Keywords

  • Autoantibodies
  • Autoimmunity
  • Dermatomyositis
  • Myopathy
  • Myositis
  • Polymyositis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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