Dereplication of phorbol bioactives: Lyngbya majuscula and croton cuneatus

John A. Beutler; Ada Belinda Alvarado; Daniel E. Schaufelberger; Pamela Andrews; Thomas G. McCloud

doi:10.1021/np50070a014

Dereplication of phorbol bioactives: Lyngbya majuscula and croton cuneatus

John A. Beutler, Ada Belinda Alvarado, Daniel E. Schaufelberger, Pamela Andrews, Thomas G. McCloud

Research output: Contribution to journal › Article › peer-review

Abstract

Lyngbya majuscula and Croton cuneatus were used as prototypes for the dereplication of phorbol ester receptor binding activity using a combination of hplc-uv and online phorbol dibutyrate (PDBu) receptor binding and batch fractionation over either Si gel or diolbonded Si gel. Debromoaplysiatoxin was responsible for the bioactivity of Lyngbya, whereas a complex of potent phorbol esters was detected in C. cuneatus.

Original language	English (US)
Pages (from-to)	867-874
Number of pages	8
Journal	Journal of Natural Products
Volume	53
Issue number	4
DOIs	https://doi.org/10.1021/np50070a014
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50070a014

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abstract = "Lyngbya majuscula and Croton cuneatus were used as prototypes for the dereplication of phorbol ester receptor binding activity using a combination of hplc-uv and online phorbol dibutyrate (PDBu) receptor binding and batch fractionation over either Si gel or diolbonded Si gel. Debromoaplysiatoxin was responsible for the bioactivity of Lyngbya, whereas a complex of potent phorbol esters was detected in C. cuneatus.",

author = "Beutler, {John A.} and Alvarado, {Ada Belinda} and Schaufelberger, {Daniel E.} and Pamela Andrews and McCloud, {Thomas G.}",

year = "1990",

doi = "10.1021/np50070a014",

language = "English (US)",

volume = "53",

pages = "867--874",

journal = "Journal of Natural Products",

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publisher = "American Chemical Society",

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T2 - Lyngbya majuscula and croton cuneatus

AU - Beutler, John A.

AU - Alvarado, Ada Belinda

AU - Schaufelberger, Daniel E.

AU - Andrews, Pamela

AU - McCloud, Thomas G.

PY - 1990

Y1 - 1990

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AB - Lyngbya majuscula and Croton cuneatus were used as prototypes for the dereplication of phorbol ester receptor binding activity using a combination of hplc-uv and online phorbol dibutyrate (PDBu) receptor binding and batch fractionation over either Si gel or diolbonded Si gel. Debromoaplysiatoxin was responsible for the bioactivity of Lyngbya, whereas a complex of potent phorbol esters was detected in C. cuneatus.

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Dereplication of phorbol bioactives: Lyngbya majuscula and croton cuneatus

Abstract

ASJC Scopus subject areas

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