Dereplication of phorbol bioactives: Lyngbya majuscula and croton cuneatus

John A. Beutler, Ada Belinda Alvarado, Daniel E. Schaufelberger, Pamela Andrews, Thomas G. McCloud

Research output: Contribution to journalArticlepeer-review

Abstract

Lyngbya majuscula and Croton cuneatus were used as prototypes for the dereplication of phorbol ester receptor binding activity using a combination of hplc-uv and online phorbol dibutyrate (PDBu) receptor binding and batch fractionation over either Si gel or diolbonded Si gel. Debromoaplysiatoxin was responsible for the bioactivity of Lyngbya, whereas a complex of potent phorbol esters was detected in C. cuneatus.

Original languageEnglish (US)
Pages (from-to)867-874
Number of pages8
JournalJournal of Natural Products
Volume53
Issue number4
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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