Deregulated estrogen receptor α expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma In situ

M. Silvina Frech, Ewa D. Halama, Maddalena T. Tilli, Baljit Singh, Edward J. Gunther, Lewis A. Chodosh, Jodi A. Flaws, Priscilla A. Furth

Research output: Contribution to journalArticlepeer-review

Abstract

A conditional tetracycline-responsive transgenic mouse model with deregulated estrogen receptor α expression in mammary epithelial cells developed ductal hyperplasia (DH), Iobular hyperplasia, and ductal carcinoma in situ (DCIS) by 4 months of age. Higher proliferative rates were found in both normal and abnormal ductal and lobular structures. DH and DCIS but not normal ductal structures showed an increased percentage of cells with nuclear-localized cyclin D1. No differences in either the prevalence or extent of these phenotypes following exogenous 17β-estradiol treatment were found suggesting that alteration of ERα expression was the rate-limiting factor in initiation of DH, lobular hyperplasia, and DCIS.

Original languageEnglish (US)
Pages (from-to)681-685
Number of pages5
JournalCancer Research
Volume65
Issue number3
StatePublished - Feb 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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