Depressive symptoms, quality of life, and neuropsychological performance in HIV/AIDS: The impact of gender and injection drug use

Amy B. Wisniewski, Samantha Apel, Ola A. Selnes, Avindra Nath, Justin Charles McArthur, Adrian S Dobs

Research output: Contribution to journalArticle

Abstract

Limited attention has been paid to the potential impact of gender and injection drug use (IDU) on mood, quality of life, and neuropsychological performance in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Several studies that describe the natural history of HIV/AIDS in terms of mental health and neuropsychological ability have focused solely on men or have excluded injection drug users. Women and injection drug users are two groups for whom the incidence of HIV infection is increasing. Additionally, the National Academy of Sciences recently recommended that studies concerned with health-related research include males and females, and that researchers analyze their data for gender differences. The goals of the current study were to investigate possible relationships between HIV and IDU status and depressive symptoms, quality of life, and neuropsychological performance in women and men matched for age, race, and education. Overall, women reported more depressive symptoms than men, and this gender difference was most evident in women who were both infected with HIV and who were also injection drug users. Women and HIV-infected individuals reported the poorest quality of life scores. Women outperformed men on a measure of verbal memory and HIV- participants outperformed HIV+ participants on a measure of perceptual speed. Finally, gender and HIV status interacted such that uninfected women performed the best, and infected men performed the worst, on a test of verbal memory. A better understanding of how men and women with different drug use profiles respond to HIV/AIDS may substantially improve survival, as well as aspects of daily functioning of affected individuals. Thus, further study and development of treatment protocols targeted at including women and IDU are needed.

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalJournal of NeuroVirology
Volume11
Issue number2
DOIs
StatePublished - Apr 2005

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Acquired Immunodeficiency Syndrome
Quality of Life
HIV
Depression
Injections
Pharmaceutical Preparations
Drug Users
Aptitude
Clinical Protocols
Natural History
HIV Infections
Mental Health
Research Personnel
Education
Survival
Incidence
Health
Research

Keywords

  • Affective disorders
  • Cognition
  • Dementia
  • Gender

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Depressive symptoms, quality of life, and neuropsychological performance in HIV/AIDS : The impact of gender and injection drug use. / Wisniewski, Amy B.; Apel, Samantha; Selnes, Ola A.; Nath, Avindra; McArthur, Justin Charles; Dobs, Adrian S.

In: Journal of NeuroVirology, Vol. 11, No. 2, 04.2005, p. 138-143.

Research output: Contribution to journalArticle

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