TY - JOUR
T1 - Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons
AU - Ammassari, Adriana
AU - Antinori, Andrea
AU - Aloisi, Maria Stella
AU - Trotta, Maria Paola
AU - Murri, Rita
AU - Bartoli, Luca
AU - D'Arminio Monforte, Antonella
AU - Wu, Albert W.
AU - Starace, Fabrizio
N1 - Funding Information:
Supported by Istituto Superiore di Sanità – II and III Programma Nazionale di Ricerca sull’AIDS and Ricerca Corrente e Finalizzata degli Istituti di Ricovero e Cura a Caratterre Scientifico . The ICONA network is supported by an educational grant from GlaxoSmithKline, Italy .
PY - 2004
Y1 - 2004
N2 - The association of depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy (HAART) was evaluated in 135 HIV-infected persons. Thirty percent reported nonadherence to HAART. Depressive symptoms (assessed with the Montgomery-Asberg Depression Rating Scale) and neurocognitive impairment (assessed with a neuropsychological test battery) were documented in 24% and 12%, respectively, of the study participants. Nonadherence to HAART was independently associated with worse depression rating scale scores (odds ratio = 1.05, 95% confidence interval [CI] = 1.00-1.10), acquisition of HIV through injection of drugs (odds ratio = 2.59, 95% CI = 1.05-6.39), and complaints about impairment of sexual activity (odds ratio = 6.62, 95% CI = 1.16-37.6). The presence of depressive symptoms, but not neurocognitive impairment, was associated with nonadherence.
AB - The association of depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy (HAART) was evaluated in 135 HIV-infected persons. Thirty percent reported nonadherence to HAART. Depressive symptoms (assessed with the Montgomery-Asberg Depression Rating Scale) and neurocognitive impairment (assessed with a neuropsychological test battery) were documented in 24% and 12%, respectively, of the study participants. Nonadherence to HAART was independently associated with worse depression rating scale scores (odds ratio = 1.05, 95% confidence interval [CI] = 1.00-1.10), acquisition of HIV through injection of drugs (odds ratio = 2.59, 95% CI = 1.05-6.39), and complaints about impairment of sexual activity (odds ratio = 6.62, 95% CI = 1.16-37.6). The presence of depressive symptoms, but not neurocognitive impairment, was associated with nonadherence.
UR - http://www.scopus.com/inward/record.url?scp=4444291864&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4444291864&partnerID=8YFLogxK
U2 - 10.1176/appi.psy.45.5.394
DO - 10.1176/appi.psy.45.5.394
M3 - Article
C2 - 15345784
AN - SCOPUS:4444291864
SN - 0033-3182
VL - 45
SP - 394
EP - 402
JO - Psychosomatics
JF - Psychosomatics
IS - 5
ER -