Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam

Sara N. Levintow, Brian W. Pence, Tran Viet Ha, Nguyen Le Minh, Teerada Sripaipan, Carl A Latkin, Pham The Vu, Vu Minh Quan, Constantine Frangakis, Vivian F. Go

Research output: Contribution to journalArticle

Abstract

People who inject drugs (PWID) with HIV experience an elevated risk of death. A potentially important determinant of survival is the high burden of depression. This study examined the relationship of depressive symptoms at HIV testing with 2-year all-cause mortality among newly diagnosed HIV-positive PWID in Vietnam. At HIV testing, 141 PWID (42%) experienced severe depressive symptoms, and over the 2 years following diagnosis, 82 PWID (24%) died. Controlling for potential confounders, the 2-year risk of death among those with depressive symptoms was 9.7% (95% CI − 1.2, 20.6%) higher than the risk among those without depressive symptoms. This increased risk of mortality for PWID with depressive symptoms was relatively consistent throughout the 2-year period: at 6, 12, and 18 months, the risk difference was 12.6% (5.5–19.7%), 13.9% (4.6–23.2%), and 11.0% (0.9–21.1%), respectively. HIV diagnosis may provide an important opportunity for depression screening and treatment, subsequently improving survival in this key population. Trial registry: ClinicalTrials.gov NCT01689545.

Original languageEnglish (US)
JournalAIDS and Behavior
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Vietnam
HIV
Depression
Mortality
Pharmaceutical Preparations
Survival
Registries
Population

Keywords

  • Depression
  • HIV
  • Injection drug use
  • Mortality
  • Vietnam

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam. / Levintow, Sara N.; Pence, Brian W.; Ha, Tran Viet; Le Minh, Nguyen; Sripaipan, Teerada; Latkin, Carl A; Vu, Pham The; Quan, Vu Minh; Frangakis, Constantine; Go, Vivian F.

In: AIDS and Behavior, 01.01.2018.

Research output: Contribution to journalArticle

Levintow, Sara N. ; Pence, Brian W. ; Ha, Tran Viet ; Le Minh, Nguyen ; Sripaipan, Teerada ; Latkin, Carl A ; Vu, Pham The ; Quan, Vu Minh ; Frangakis, Constantine ; Go, Vivian F. / Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam. In: AIDS and Behavior. 2018.
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