Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans

Abraham A. Ariyo, Mary Haan, Catherine M. Tangen, John C. Rutledge, Mary Cushman, Adrian S Dobs, Curt D. Furberg

Research output: Contribution to journalArticle

Abstract

Background - Several epidemiological studies have associated depressive symptoms with cardiovascular disease. We investigated whether depressive symptoms constituted a risk for coronary heart disease (CHD) and total mortality among an apparently healthy elderly cohort. Methods and Results - In a prospective cohort of 5888 elderly Americans (≥65 years) who were enrolled in the Cardiovascular Health Study, 4493 participants who were free of cardiovascular disease at baseline provided annual information on their depressive status, which was assessed using the Depression Scale of the Center for Epidemiological Studies. These 4493 subjects were followed for 6 years for the development of CHD and mortality. The cumulative mean depression score was assessed for each participant up to the time of event (maximum 6-year follow-up). Using time-dependent, proportional-hazards models, the unadjusted hazard ratio associated with every 5-unit increase in mean depression score for the development of CHD was 1.15 (P=0.006); the ratio for all-cause mortality was 1.29 (P

Original languageEnglish (US)
Pages (from-to)1773-1779
Number of pages7
JournalCirculation
Volume102
Issue number15
StatePublished - Oct 10 2000

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Coronary Disease
Depression
Mortality
Epidemiologic Studies
Cardiovascular Diseases
Proportional Hazards Models
Health

Keywords

  • Coronary disease
  • Depression
  • Epidemiology
  • Mortality
  • Risk factors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Ariyo, A. A., Haan, M., Tangen, C. M., Rutledge, J. C., Cushman, M., Dobs, A. S., & Furberg, C. D. (2000). Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. Circulation, 102(15), 1773-1779.

Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. / Ariyo, Abraham A.; Haan, Mary; Tangen, Catherine M.; Rutledge, John C.; Cushman, Mary; Dobs, Adrian S; Furberg, Curt D.

In: Circulation, Vol. 102, No. 15, 10.10.2000, p. 1773-1779.

Research output: Contribution to journalArticle

Ariyo, AA, Haan, M, Tangen, CM, Rutledge, JC, Cushman, M, Dobs, AS & Furberg, CD 2000, 'Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans', Circulation, vol. 102, no. 15, pp. 1773-1779.
Ariyo AA, Haan M, Tangen CM, Rutledge JC, Cushman M, Dobs AS et al. Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. Circulation. 2000 Oct 10;102(15):1773-1779.
Ariyo, Abraham A. ; Haan, Mary ; Tangen, Catherine M. ; Rutledge, John C. ; Cushman, Mary ; Dobs, Adrian S ; Furberg, Curt D. / Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. In: Circulation. 2000 ; Vol. 102, No. 15. pp. 1773-1779.
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