@article{0fcce39d58274b71a0a190f7e0df802d,
title = "Depressive symptoms and CSF Alzheimer's disease biomarkers in relation to clinical symptom onset of mild cognitive impairment",
abstract = "Introduction: We sought to examine whether depressive symptoms and level of Alzheimer's disease (AD) pathology are independently or interactively associated with the risk of progression to mild cognitive impairment (MCI). Methods: The study included a total of 216 participants from the Biomarkers for Older Controls at Risk for Alzheimer's Disease study, a cohort of individuals who were cognitively normal at baseline (mean age = 57) and followed for more than 20 years (mean = 12.7 years), who had baseline Hamilton Depression Scale (HAM-D) scores and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, t-tau, and p-tau measures available. Results: Cox regression demonstrated that baseline HAM-D and CSF AD biomarkers were both associated with time to onset of MCI. There was an interaction between HAM-D scores and markers of AD pathology, in which depression was associated with time of onset in participants with low levels of AD pathology (hazard ratio = 0.64; 95% confidence interval = 0.43–0.95; P=.026). Discussion: The effect of depressive symptoms on progression to clinical symptoms of MCI may be most evident among individuals with low levels of AD pathology.",
keywords = "Alzheimer's disease, amyloid, cerebrospinal fluid, depression, mild behavioral impairment, mild cognitive impairment, p-tau, t-tau, vascular disease",
author = "{the BIOCARD Research Team} and Chan, {Carol K.} and Anja Soldan and Corinne Pettigrew and Jiangxia Wang and Marilyn Albert and Rosenberg, {Paul B.} and Marilyn Albert and Rostislav Brichko and Rebecca Gottesman and Ned Sacktor and Scott Turner and Leonie Farrington and Maura Grega and Gay Rudow and Daniel D{\textquoteright}Agostino and Scott Rudow and Michael Miller and Susumu Mori and Tilak Ratnanather and Timothy Brown and Hayan Chi and Anthony Kolasny and Kenichi Oishi and Laurent Younes and Abhay Moghekar and Richard O{\textquoteright}Brien and Roberta Scherer and David Shade and Ann Ervin and Jennifer Jones and Hamadou Coulibaly and April Patterson and Wang, {Mei Cheng} and Daisy Zhu and Juan Troncoso and Barbara Crain and Olga Pletnikova and Karen Fisher and John Cernansky and David Holtzman and David Knopman and Walter Kukull and Kevin Grimm and John Hsiao and Laurie Ryan and Constantine Lyketsos and Carlos Pardo and Gerard Schellenberg and Leslie Shaw and Madhav Thambisetty",
note = "Funding Information: This work was supported by the National Institutes of Health (grant numbers U19-AG033655, P50-AG005146). The BIOCARD Study consists of seven Cores with the following members: (1) the Administrative Core (Marilyn Albert, Rostislav Brichko); (2) the Clinical Core (Marilyn Albert, Anja Soldan, Corinne Pettigrew, Rebecca Gottesman, Ned Sacktor, Scott Turner, Leonie Farrington, Maura Grega, Gay Rudow, Daniel D'Agostino, Scott Rudow); (3) the Imaging Core (Michael Miller, Susumu Mori, Tilak Ratnanather, Timothy Brown, Hayan Chi, Anthony Kolasny, Kenichi Oishi, Laurent Younes); (4) the Biospecimen Core (Abhay Moghekar, Richard O'Brien); (5) the Informatics Core (Roberta Scherer, David Shade, Ann Ervin, Jennifer Jones, Hamadou Coulibaly, April Patterson); (6) the Biostatistics Core (Mei-Cheng Wang, Daisy Zhu, Jiangxia Wang); and (7) the Neuropathology Core (Juan Troncoso, Barbara Crain, Olga Pletnikova, Gay Rudow, Karen Fisher). The authors are grateful to the members of the BIOCARD Scientific Advisory Board who provide continued oversight and guidance regarding the conduct of the study including: Drs. John Cernansky, David Holtzman, David Knopman, Walter Kukull, and Kevin Grimm, and Drs John Hsiao and Laurie Ryan, who provide oversight on behalf of the National Institute on Aging. The authors thank the members of the BIOCARD Resource Allocation Committee who provide ongoing guidance regarding the use of the biospecimens collected as part of the study, including: Drs. Constantine Lyketsos, Carlos Pardo, Gerard Schellenberg, Leslie Shaw, Madhav Thambisetty, and John Trojanowski. The authors acknowledge the contributions of the Geriatric Psychiatry Branch of the intramural program of NIMH who initiated the study (principal investigator: Dr. Trey Sunderland). The authors are particularly indebted to Dr. Karen Putnam, who has provided ongoing documentation of the Geriatric Psychiatry Branch study procedures and the data files received from NIMH. Funding Information: This work was supported by the National Institutes of Health (grant numbers U19‐AG033655, P50‐AG005146). Publisher Copyright: {\textcopyright} 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association",
year = "2020",
doi = "10.1002/dad2.12106",
language = "English (US)",
volume = "12",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",
number = "1",
}