Depression screening and patient outcomes in cardiovascular care: A systematic review

Brett D. Thombs, Peter De Jonge, James C. Coyne, Mary A. Whooley, Nancy Frasure-Smith, Alex J. Mitchell, Marij Zuidersma, Chete Eze-Nliam, Bruno B. Lima, Cheri G. Smith, Karl Soderlund, Roy Ziegelstein

Research output: Contribution to journalArticle

Abstract

Context: Several practice guidelines recommend that depression be evaluated and treated in patients with cardiovascular disease, but the potential benefits of this are unclear. Objective: To evaluate the potential benefits of depression screening in patients with cardiovascular disease by assessing (1) the accuracy of depression screening instruments; (2) the effect of depression treatment on depression and cardiac outcomes; and (3) the effect of screening on depression and cardiac outcomes in patients in cardiovascular care settings. Data Sources: MEDLINE, PsycINFO, CINAHL, EMBASE, ISI, SCOPUS, and Cochrane databases from inception to May 1, 2008; manual journal searches; reference list reviews; and citation tracking of included articles. Study Selection: We included articles in any language about patients in cardiovascular care settings that (1) compared a screening instrument to a valid major depressive disorder criterion standard; (2) compared depression treatment with placebo or usual care in a randomized controlled trial; or (3) assessed the effect of screening on depression identification and treatment rates, depression, or cardiac outcomes. Data Extraction: Methodological characteristics and outcomes were extracted by 2 investigators. Results: We identified 11 studies about screening accuracy, 6 depression treatment trials, but no studies that evaluated the effects of screening on depression or cardiovascular outcomes. In studies that tested depression screening instruments using a prioridefined cutoff scores, sensitivity ranged from 39% to 100% (median, 84%) and specificity ranged from 58% to 94% (median, 79%). Depression treatment with medication or cognitive behavioral therapy resulted in modest reductions in depressive symptoms (effect size, 0.20-0.38; r2, 1%-4%). There was no evidence that depression treatment improved cardiac outcomes. Among patients with depression and history of myocardial infarction in the ENRICHD trial, there was no difference in event-free survival between participants treated with cognitive behavioral therapy supplemented by an antidepressant vs usual care (75.5% vs 74.7%, respectively). Conclusions: Depression treatment with medication or cognitive behavioral therapy in patients with cardiovascular disease is associated with modest improvement in depressive symptoms but no improvement in cardiac outcomes. No clinical trials have assessed whether screening for depression improves depressive symptoms or cardiac outcomes in patients with cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)2161-2171
Number of pages11
JournalJournal of the American Medical Association
Volume300
Issue number18
DOIs
StatePublished - Nov 12 2008

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Depression
Cognitive Therapy
Cardiovascular Diseases
Therapeutics
Information Storage and Retrieval
Major Depressive Disorder
Practice Guidelines
MEDLINE
Antidepressive Agents
Disease-Free Survival
Language
Randomized Controlled Trials
Myocardial Infarction
Placebos
Research Personnel
Clinical Trials
Databases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thombs, B. D., De Jonge, P., Coyne, J. C., Whooley, M. A., Frasure-Smith, N., Mitchell, A. J., ... Ziegelstein, R. (2008). Depression screening and patient outcomes in cardiovascular care: A systematic review. Journal of the American Medical Association, 300(18), 2161-2171. https://doi.org/10.1001/jama.2008.667

Depression screening and patient outcomes in cardiovascular care : A systematic review. / Thombs, Brett D.; De Jonge, Peter; Coyne, James C.; Whooley, Mary A.; Frasure-Smith, Nancy; Mitchell, Alex J.; Zuidersma, Marij; Eze-Nliam, Chete; Lima, Bruno B.; Smith, Cheri G.; Soderlund, Karl; Ziegelstein, Roy.

In: Journal of the American Medical Association, Vol. 300, No. 18, 12.11.2008, p. 2161-2171.

Research output: Contribution to journalArticle

Thombs, BD, De Jonge, P, Coyne, JC, Whooley, MA, Frasure-Smith, N, Mitchell, AJ, Zuidersma, M, Eze-Nliam, C, Lima, BB, Smith, CG, Soderlund, K & Ziegelstein, R 2008, 'Depression screening and patient outcomes in cardiovascular care: A systematic review', Journal of the American Medical Association, vol. 300, no. 18, pp. 2161-2171. https://doi.org/10.1001/jama.2008.667
Thombs BD, De Jonge P, Coyne JC, Whooley MA, Frasure-Smith N, Mitchell AJ et al. Depression screening and patient outcomes in cardiovascular care: A systematic review. Journal of the American Medical Association. 2008 Nov 12;300(18):2161-2171. https://doi.org/10.1001/jama.2008.667
Thombs, Brett D. ; De Jonge, Peter ; Coyne, James C. ; Whooley, Mary A. ; Frasure-Smith, Nancy ; Mitchell, Alex J. ; Zuidersma, Marij ; Eze-Nliam, Chete ; Lima, Bruno B. ; Smith, Cheri G. ; Soderlund, Karl ; Ziegelstein, Roy. / Depression screening and patient outcomes in cardiovascular care : A systematic review. In: Journal of the American Medical Association. 2008 ; Vol. 300, No. 18. pp. 2161-2171.
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abstract = "Context: Several practice guidelines recommend that depression be evaluated and treated in patients with cardiovascular disease, but the potential benefits of this are unclear. Objective: To evaluate the potential benefits of depression screening in patients with cardiovascular disease by assessing (1) the accuracy of depression screening instruments; (2) the effect of depression treatment on depression and cardiac outcomes; and (3) the effect of screening on depression and cardiac outcomes in patients in cardiovascular care settings. Data Sources: MEDLINE, PsycINFO, CINAHL, EMBASE, ISI, SCOPUS, and Cochrane databases from inception to May 1, 2008; manual journal searches; reference list reviews; and citation tracking of included articles. Study Selection: We included articles in any language about patients in cardiovascular care settings that (1) compared a screening instrument to a valid major depressive disorder criterion standard; (2) compared depression treatment with placebo or usual care in a randomized controlled trial; or (3) assessed the effect of screening on depression identification and treatment rates, depression, or cardiac outcomes. Data Extraction: Methodological characteristics and outcomes were extracted by 2 investigators. Results: We identified 11 studies about screening accuracy, 6 depression treatment trials, but no studies that evaluated the effects of screening on depression or cardiovascular outcomes. In studies that tested depression screening instruments using a prioridefined cutoff scores, sensitivity ranged from 39{\%} to 100{\%} (median, 84{\%}) and specificity ranged from 58{\%} to 94{\%} (median, 79{\%}). Depression treatment with medication or cognitive behavioral therapy resulted in modest reductions in depressive symptoms (effect size, 0.20-0.38; r2, 1{\%}-4{\%}). There was no evidence that depression treatment improved cardiac outcomes. Among patients with depression and history of myocardial infarction in the ENRICHD trial, there was no difference in event-free survival between participants treated with cognitive behavioral therapy supplemented by an antidepressant vs usual care (75.5{\%} vs 74.7{\%}, respectively). Conclusions: Depression treatment with medication or cognitive behavioral therapy in patients with cardiovascular disease is associated with modest improvement in depressive symptoms but no improvement in cardiac outcomes. No clinical trials have assessed whether screening for depression improves depressive symptoms or cardiac outcomes in patients with cardiovascular disease.",
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N2 - Context: Several practice guidelines recommend that depression be evaluated and treated in patients with cardiovascular disease, but the potential benefits of this are unclear. Objective: To evaluate the potential benefits of depression screening in patients with cardiovascular disease by assessing (1) the accuracy of depression screening instruments; (2) the effect of depression treatment on depression and cardiac outcomes; and (3) the effect of screening on depression and cardiac outcomes in patients in cardiovascular care settings. Data Sources: MEDLINE, PsycINFO, CINAHL, EMBASE, ISI, SCOPUS, and Cochrane databases from inception to May 1, 2008; manual journal searches; reference list reviews; and citation tracking of included articles. Study Selection: We included articles in any language about patients in cardiovascular care settings that (1) compared a screening instrument to a valid major depressive disorder criterion standard; (2) compared depression treatment with placebo or usual care in a randomized controlled trial; or (3) assessed the effect of screening on depression identification and treatment rates, depression, or cardiac outcomes. Data Extraction: Methodological characteristics and outcomes were extracted by 2 investigators. Results: We identified 11 studies about screening accuracy, 6 depression treatment trials, but no studies that evaluated the effects of screening on depression or cardiovascular outcomes. In studies that tested depression screening instruments using a prioridefined cutoff scores, sensitivity ranged from 39% to 100% (median, 84%) and specificity ranged from 58% to 94% (median, 79%). Depression treatment with medication or cognitive behavioral therapy resulted in modest reductions in depressive symptoms (effect size, 0.20-0.38; r2, 1%-4%). There was no evidence that depression treatment improved cardiac outcomes. Among patients with depression and history of myocardial infarction in the ENRICHD trial, there was no difference in event-free survival between participants treated with cognitive behavioral therapy supplemented by an antidepressant vs usual care (75.5% vs 74.7%, respectively). Conclusions: Depression treatment with medication or cognitive behavioral therapy in patients with cardiovascular disease is associated with modest improvement in depressive symptoms but no improvement in cardiac outcomes. No clinical trials have assessed whether screening for depression improves depressive symptoms or cardiac outcomes in patients with cardiovascular disease.

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