Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation

R. Chen, J. Classen, C. Gerloff, P. Celnik, E. M. Wassermann, M. Hallett, Leonardo G. Cohen

Research output: Contribution to journalArticlepeer-review


We studied the effects of low-frequency transcranial magnetic stimulation (TMS) on motor cortex excitability in humans. TMS at 0.1 Hz for 1 hour did not change cortical excitability. Stimulation at 0.9 Hz for 15 minutes (810 pulses), similar to the parameters used to induce long-term depression (LTD) in cortical slice preparations and in vivo animal studies, led to a mean decrease in motor evoked potential (MEP) amplitude of 19.5%. The decrease in cortical excitability lasted for at least 15 minutes after the end of the 0.9 Hz stimulation. The mechanism underlying this decrease in excitability may be similar to LTD. TMS-induced reduction of cortical excitability has potential clinical applications in diseases such as epilepsy and myoclonus. Spread of excitation, which may be a warning sign for seizures, occurred in one subject and was not accompanied by increased MEP amplitude, suggesting that spread of excitation and amplitude changes are different phenomena and also indicating the need for adequate monitoring even with stimulations at low frequencies.

Original languageEnglish (US)
Pages (from-to)1398-1403
Number of pages6
Issue number5
StatePublished - May 1997
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation'. Together they form a unique fingerprint.

Cite this