Depression of human myocardial contractility with "respiratory" and "metabolic" acidosis

Horacio E. Cingolani; Scott L. Faulkner; Alicia R. Mattiazzi; Harvey W. Bender; Thomas P. Graham

Depression of human myocardial contractility with "respiratory" and "metabolic" acidosis

Horacio E. Cingolani, Scott L. Faulkner, Alicia R. Mattiazzi, Harvey W. Bender, Thomas P. Graham

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

The effect of a similar degree of "respiratory" and "metabolic" acidosis was studied in seven isolated in vitro human pectinate muscles and eight ventricular muscle bundles. Either "respiratory" or "metabolic" acidosis (from 7.36 ± 0.03 to 7.01 ± 0.02 and 6.98 ± 0.03, respectively) depressed in vitro contractility in human atrial or ventricular muscle to a similar extent. Previous contradictory responses of myocardial tissue to alterations in pH appear to be the result of species differences.

Original language	English (US)
Pages (from-to)	427-432
Number of pages	6
Journal	Surgery
Volume	77
Issue number	3
State	Published - Mar 1975

ASJC Scopus subject areas

Surgery

Cite this

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AU - Cingolani, Horacio E.

AU - Faulkner, Scott L.

AU - Mattiazzi, Alicia R.

AU - Bender, Harvey W.

AU - Graham, Thomas P.

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N2 - The effect of a similar degree of "respiratory" and "metabolic" acidosis was studied in seven isolated in vitro human pectinate muscles and eight ventricular muscle bundles. Either "respiratory" or "metabolic" acidosis (from 7.36 ± 0.03 to 7.01 ± 0.02 and 6.98 ± 0.03, respectively) depressed in vitro contractility in human atrial or ventricular muscle to a similar extent. Previous contradictory responses of myocardial tissue to alterations in pH appear to be the result of species differences.

AB - The effect of a similar degree of "respiratory" and "metabolic" acidosis was studied in seven isolated in vitro human pectinate muscles and eight ventricular muscle bundles. Either "respiratory" or "metabolic" acidosis (from 7.36 ± 0.03 to 7.01 ± 0.02 and 6.98 ± 0.03, respectively) depressed in vitro contractility in human atrial or ventricular muscle to a similar extent. Previous contradictory responses of myocardial tissue to alterations in pH appear to be the result of species differences.

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Depression of human myocardial contractility with "respiratory" and "metabolic" acidosis

Abstract

ASJC Scopus subject areas

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