Depression of human myocardial contractility with "respiratory" and "metabolic" acidosis

Horacio E. Cingolani, Scott L. Faulkner, Alicia R. Mattiazzi, Harvey W. Bender, Thomas P. Graham

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


The effect of a similar degree of "respiratory" and "metabolic" acidosis was studied in seven isolated in vitro human pectinate muscles and eight ventricular muscle bundles. Either "respiratory" or "metabolic" acidosis (from 7.36 ± 0.03 to 7.01 ± 0.02 and 6.98 ± 0.03, respectively) depressed in vitro contractility in human atrial or ventricular muscle to a similar extent. Previous contradictory responses of myocardial tissue to alterations in pH appear to be the result of species differences.

Original languageEnglish (US)
Pages (from-to)427-432
Number of pages6
Issue number3
StatePublished - Mar 1975

ASJC Scopus subject areas

  • Surgery


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