Abstract
We investigated the associations between depressive symptoms and adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV). We searched the PubMed, EMBASE and Cochrane CENTRAL databases for studies that reported an association between depression and adherence to ART as a primary or secondary outcome. We used a random-effect model to pool the risk estimates from the individual studies. The odds ratio (OR) with their 95 % CIs were used as summary estimates. Of 2861 citations, 111 studies that recruited 42,366 PLHIV met our inclusion criteria. When reported, the rate of PLHIV with depressive symptoms ranged from 12.8 to 78 % and the proportion of PLHIV who achieved good adherence (≥ 80 %) ranged from 20 to 98 %. There were no significant differences in rate of depressive symptoms in PLHIV by country income group; however, the proportion of PLHIV who achieved good adherence was significantly higher in lower-income countries (as defined in the 2012 World Bank Country Income Groups) (pooled rate=86 %) compared to higher-income countries (pooled rate=67.5 %; p
| Original language | English (US) |
|---|---|
| Pages (from-to) | 291-307 |
| Number of pages | 17 |
| Journal | Joint Commission Journal on Quality and Patient Safety |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2014 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries : a systematic review and meta-analysis. / Uthman, Olalekan A.; Magidson, Jessica F.; Safren, Steven A.; Nachega, Jean B.
In: Joint Commission Journal on Quality and Patient Safety, Vol. 11, No. 3, 01.09.2014, p. 291-307.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries
T2 - a systematic review and meta-analysis
AU - Uthman, Olalekan A.
AU - Magidson, Jessica F.
AU - Safren, Steven A.
AU - Nachega, Jean B.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - We investigated the associations between depressive symptoms and adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV). We searched the PubMed, EMBASE and Cochrane CENTRAL databases for studies that reported an association between depression and adherence to ART as a primary or secondary outcome. We used a random-effect model to pool the risk estimates from the individual studies. The odds ratio (OR) with their 95 % CIs were used as summary estimates. Of 2861 citations, 111 studies that recruited 42,366 PLHIV met our inclusion criteria. When reported, the rate of PLHIV with depressive symptoms ranged from 12.8 to 78 % and the proportion of PLHIV who achieved good adherence (≥ 80 %) ranged from 20 to 98 %. There were no significant differences in rate of depressive symptoms in PLHIV by country income group; however, the proportion of PLHIV who achieved good adherence was significantly higher in lower-income countries (as defined in the 2012 World Bank Country Income Groups) (pooled rate=86 %) compared to higher-income countries (pooled rate=67.5 %; p
AB - We investigated the associations between depressive symptoms and adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV). We searched the PubMed, EMBASE and Cochrane CENTRAL databases for studies that reported an association between depression and adherence to ART as a primary or secondary outcome. We used a random-effect model to pool the risk estimates from the individual studies. The odds ratio (OR) with their 95 % CIs were used as summary estimates. Of 2861 citations, 111 studies that recruited 42,366 PLHIV met our inclusion criteria. When reported, the rate of PLHIV with depressive symptoms ranged from 12.8 to 78 % and the proportion of PLHIV who achieved good adherence (≥ 80 %) ranged from 20 to 98 %. There were no significant differences in rate of depressive symptoms in PLHIV by country income group; however, the proportion of PLHIV who achieved good adherence was significantly higher in lower-income countries (as defined in the 2012 World Bank Country Income Groups) (pooled rate=86 %) compared to higher-income countries (pooled rate=67.5 %; p
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U2 - 10.1007/s11904-014-0220-1
DO - 10.1007/s11904-014-0220-1
M3 - Article
C2 - 25038748
VL - 11
SP - 291
EP - 307
JO - Nature Clinical Practice Oncology
JF - Nature Clinical Practice Oncology
SN - 1759-4774
IS - 3
ER -