TY - JOUR
T1 - Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity
T2 - The effect of aerobic training and energy restriction
AU - Yamashita, Alex Shimura
AU - Lira, Fábio Santos
AU - Rosa, José Cesar
AU - Paulino, Ellena Christina
AU - Brum, Patrícia Chakur
AU - Negrão, Carlos Eduardo
AU - dos Santos, Ronaldo Vagner
AU - Batista, Miguel Luiz
AU - Oller do Nascimento, Claudia
AU - Oyama, Lila Missae
AU - Seelaender, Marília
N1 - Funding Information:
The authors thank Emilia Ribeiro for valuable technical assistance. This work was supported by Grant Nos. 04/11588-0 and 05/01445-0 FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo).
PY - 2010
Y1 - 2010
N2 - The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n=8) or trained (trained HFD, n=8); or submitted to energy-restriction (ER), which were sedentary (sedentary ER, n=8) or trained (trained ER, n=8). Trained rats ran on a treadmill at 55% VO2max for 60min/day, 5days/week, for 10weeks. ER rats were submitted to a reduction of 20% daily caloric ingestion compared to the Control group. ER and aerobic training decreased body weight, MEAT and RPAT absolute weight, and fat mass. IL-6, IL-10 and TNF-α levels were decreased and adiponectin did not change in RPAT in response to ER protocol. On the other hand, ER and the aerobic training protocol decreased IL-6, TNF-α and adiponectin levels in MEAT. Absolute MEAT weight showed a positive correlation with IL-6 (r=0.464), TNF-α (r=0.508); and adiponectin (r=0.342). These results suggest a tissue-specific heterogeneous response in adipokines level. The combination of the protocols (aerobic training and energy restriction) did not induce an enhanced effect.
AB - The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n=8) or trained (trained HFD, n=8); or submitted to energy-restriction (ER), which were sedentary (sedentary ER, n=8) or trained (trained ER, n=8). Trained rats ran on a treadmill at 55% VO2max for 60min/day, 5days/week, for 10weeks. ER rats were submitted to a reduction of 20% daily caloric ingestion compared to the Control group. ER and aerobic training decreased body weight, MEAT and RPAT absolute weight, and fat mass. IL-6, IL-10 and TNF-α levels were decreased and adiponectin did not change in RPAT in response to ER protocol. On the other hand, ER and the aerobic training protocol decreased IL-6, TNF-α and adiponectin levels in MEAT. Absolute MEAT weight showed a positive correlation with IL-6 (r=0.464), TNF-α (r=0.508); and adiponectin (r=0.342). These results suggest a tissue-specific heterogeneous response in adipokines level. The combination of the protocols (aerobic training and energy restriction) did not induce an enhanced effect.
KW - Adipokines
KW - Aerobic training
KW - Energy restriction
KW - White adipose tissue
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U2 - 10.1016/j.cyto.2010.07.006
DO - 10.1016/j.cyto.2010.07.006
M3 - Article
C2 - 20728374
AN - SCOPUS:79953308134
SN - 1043-4666
VL - 52
SP - 168
EP - 174
JO - Cytokine
JF - Cytokine
IS - 3
ER -