Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: The effect of aerobic training and energy restriction

Alex Shimura Yamashita, Fábio Santos Lira, José Cesar Rosa, Ellena Christina Paulino, Patrícia Chakur Brum, Carlos Eduardo Negrão, Ronaldo Vagner dos Santos, Miguel Luiz Batista, Claudia Oller do Nascimento, Lila Missae Oyama, Marília Seelaender

Research output: Contribution to journalArticlepeer-review

Abstract

The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n=8) or trained (trained HFD, n=8); or submitted to energy-restriction (ER), which were sedentary (sedentary ER, n=8) or trained (trained ER, n=8). Trained rats ran on a treadmill at 55% VO2max for 60min/day, 5days/week, for 10weeks. ER rats were submitted to a reduction of 20% daily caloric ingestion compared to the Control group. ER and aerobic training decreased body weight, MEAT and RPAT absolute weight, and fat mass. IL-6, IL-10 and TNF-α levels were decreased and adiponectin did not change in RPAT in response to ER protocol. On the other hand, ER and the aerobic training protocol decreased IL-6, TNF-α and adiponectin levels in MEAT. Absolute MEAT weight showed a positive correlation with IL-6 (r=0.464), TNF-α (r=0.508); and adiponectin (r=0.342). These results suggest a tissue-specific heterogeneous response in adipokines level. The combination of the protocols (aerobic training and energy restriction) did not induce an enhanced effect.

Original languageEnglish (US)
Pages (from-to)168-174
Number of pages7
JournalCytokine
Volume52
Issue number3
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Adipokines
  • Aerobic training
  • Energy restriction
  • White adipose tissue

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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