Depletion of peripheral-type benzodiazepine receptors after hypophysectomy in rat adrenal gland and testis

Robert R.H. Anholt, Errol B. De Souza, Michael J. Kuhar, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the effect of hypophysectomy in rats on peripheral-type benzodiazepine receptors in the adrenal gland and testis. Following removal of the pituitary, binding sites for [3H]Ro5-4864, a ligand selective for peripheral-type benzodiazepine receptors, are depleted in these tissues in parallel with their atrophy. This reduction in receptor levels appears to be a primary effect of the hypophysectomy, since castration has no effect on benzodiazepine receptors in the adrenal gland, nor does adrenalectomy influence testicular levels of these receptors. Our results indicate that peripheral-type benzodiazepine receptors in these steroidogenic organs are localized to cells which are dependent on trophic maintenance by the pituitary.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalEuropean Journal of Pharmacology
Volume110
Issue number1
DOIs
StatePublished - Mar 26 1985

Keywords

  • Endocrine glands
  • Hypophysectomy
  • Peripheral-type benzodiazepine receptors
  • Ro5-4864

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Depletion of peripheral-type benzodiazepine receptors after hypophysectomy in rat adrenal gland and testis'. Together they form a unique fingerprint.

Cite this