Dependence of Brain Intravoxel Incoherent Motion Perfusion Parameters on the Cardiac Cycle

Christian Federau, Patric Hagmann, Philippe Maeder, Markus Müller, Reto Meuli, Matthias Stuber, Kieran O'Brien

Research output: Contribution to journalArticlepeer-review

Abstract

Measurement of microvascular perfusion with Intravoxel Incoherent Motion (IVIM) MRI is gaining interest. Yet, the physiological influences on the IVIM perfusion parameters ("pseudo-diffusion" coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. We extended the IVIM model to include time dependence of D* = D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. The results non-invasively demonstrate the pulsatility of the brain's microvasculature.

Original languageEnglish (US)
Article numbere72856
JournalPloS one
Volume8
Issue number8
DOIs
StatePublished - Aug 30 2013
Externally publishedYes

ASJC Scopus subject areas

  • General

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