Dengue virus (DENV) neutralizing antibody kinetics in children after symptomatic primary and postprimary DENV infection

Hannah E. Clapham, Isabel Rodriguez-Barraquer, Andrew S. Azman, Benjamin M. Althouse, Henrik Salje, Robert V. Gibbons, Alan L. Rothman, Richard G. Jarman, Ananda Nisalak, Butsaya Thaisomboonsuk, Siripen Kalayanarooj, Suchitra Nimmannitya, David W. Vaughn, Sharone Green, In Kyu Yoon, Derek A T Cummings

Research output: Contribution to journalArticlepeer-review

Abstract

The immune response to dengue virus (DENV) infection is complex and not fully understood. Using longitudinal data from 181 children with dengue in Thailand who were followed for up to 3 years, we describe neutralizing antibody kinetics following symptomatic DENV infection. We observed that antibody titers varied by serotype, homotypic vs heterotypic responses, and primary versus postprimary infections. The rates of change in antibody titers over time varied between primary and postprimary responses. For primary infections, titers increased from convalescence to 6 months. By comparing homotypic and heterotypic antibody titers, we saw an increase in type specificity from convalescence to 6 months for primary DENV3 infections but not primary DENV1 infections. In postprimary cases, there was a decrease in titers from convalescence up until 6 months after infection. Beginning 1 year after both primary and postprimary infections, there was evidence of increasing antibody titers, with greater increases in children with lower titers, suggesting that antibody titers were boosted due to infection and that higher levels of neutralizing antibody may be more likely to confer a sterilizing immune response. These findings may help to model virus transmission dynamics and provide baseline data to support the development of vaccines and therapeutics.

Original languageEnglish (US)
Pages (from-to)1428-1435
Number of pages8
JournalJournal of Infectious Diseases
Volume213
Issue number9
DOIs
StatePublished - May 1 2016

Keywords

  • Dengue
  • Longitudinal antibody kinetics
  • Neutralizing antibody
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Medicine(all)
  • Infectious Diseases

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