Dengue Antibody and Zika: Friend or Foe?

Anna P. Durbin

doi:10.1016/j.it.2016.08.006

Dengue Antibody and Zika: Friend or Foe?

Anna P. Durbin

Bloomberg School of Public Health

Research output: Contribution to journal › Short survey › peer-review

30 Scopus citations

Abstract

Zika virus is a mosquito-borne Flavivirus related to dengue that is rapidly spreading through the Americas. This outbreak is occurring in dengue-endemic areas where the population has acquired antibodies to dengue. Recent studies reveal that preexisting dengue antibodies may have opposite effects on Zika infection, transmission, and clinical outcome. Discerning these effects is critical to a better understanding of Zika pathogenesis and the prevention of future outbreaks.

Original language	English (US)
Pages (from-to)	635-636
Number of pages	2
Journal	Trends in Immunology
Volume	37
Issue number	10
DOIs	https://doi.org/10.1016/j.it.2016.08.006
State	Published - Oct 1 2016

Keywords

Zika virus
antibody-dependent enhancement of infection
dengue virus

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.it.2016.08.006

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title = "Dengue Antibody and Zika: Friend or Foe?",

abstract = "Zika virus is a mosquito-borne Flavivirus related to dengue that is rapidly spreading through the Americas. This outbreak is occurring in dengue-endemic areas where the population has acquired antibodies to dengue. Recent studies reveal that preexisting dengue antibodies may have opposite effects on Zika infection, transmission, and clinical outcome. Discerning these effects is critical to a better understanding of Zika pathogenesis and the prevention of future outbreaks.",

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AB - Zika virus is a mosquito-borne Flavivirus related to dengue that is rapidly spreading through the Americas. This outbreak is occurring in dengue-endemic areas where the population has acquired antibodies to dengue. Recent studies reveal that preexisting dengue antibodies may have opposite effects on Zika infection, transmission, and clinical outcome. Discerning these effects is critical to a better understanding of Zika pathogenesis and the prevention of future outbreaks.

KW - Zika virus

KW - antibody-dependent enhancement of infection

KW - dengue virus

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ER -

Dengue Antibody and Zika: Friend or Foe?

Abstract

Keywords

ASJC Scopus subject areas

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