Dendritic Cell Therapy in Composite Tissue Allotransplantation

A. W. Thomson, J. M. Sacks, Y. R. Kuo, R. Ikeguchi, E. K. Horibe, J. Unadkat, M. G. Solari, M. Feili-Hariri, W. P.A. Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy.

Original languageEnglish (US)
Pages (from-to)537-538
Number of pages2
JournalTransplantation proceedings
Volume41
Issue number2
DOIs
StatePublished - Mar 2009

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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