Dendritic cell function and antigen presentation in malaria

Ian A. Cockburn, Fidel Zavala

Research output: Contribution to journalReview article

Abstract

Due to the diverse roles T cells play in protection against malaria as well as pathogenesis it is critical to know which cells present antigen and the nature of the antigens they present. During pre-erythrocytic stages of infection, cutting-edge imaging studies have shown how Plasmodium antigens are presented during both the priming and effector phases of the protective CD8+ T cell response. During blood stages, pathology is in part due to the loss of DC function and the action of pathogenic T cells in the brain. Recently endothelial cells presenting malaria antigen to cognate T cells have emerged as critical players in malaria pathogenesis. Manipulating these processes may inform both vaccine design and the development of therapies for cerebral malaria.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCurrent Opinion in Immunology
Volume40
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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