Dendritic anomalies in disorders associated with mental retardation

Walter E. Kaufmann, Hugo W. Moser

    Research output: Contribution to journalArticle

    Abstract

    Dendritic abnormalities are the most consistent anatomical correlates of mental retardation (MR). Earliest descriptions included dendritic spine dysgenesis, which was first associated with unclassified MR, but can also be found in genetic syndromes associated with MR. Genetic disorders with well-defined dendritic anomalies involving branches and/or spines include Down, Rett and fragile-X syndromes. Cytoarchitectonic analyses also suggest dendritic pathology in Williams and Rubinstein-Taybi syndromes. Dendritic abnormalities appear to have syndrome-specific pathogenesis and evolution, which correlate to some extent with their cognitive profile. The significance of dendritic pathology in synaptic circuitry and the role of animal models in the study of MR-associated dendritic abnormalities are also discussed. Finally, a model of genotype to neurologic phenotype pathway in MR, centered in dendritic abnormalities, is postulated.

    Original languageEnglish (US)
    Pages (from-to)981-991
    Number of pages11
    JournalCerebral Cortex
    Volume10
    Issue number10
    StatePublished - 2000

    Fingerprint

    Intellectual Disability
    Rubinstein-Taybi Syndrome
    Pathology
    Fragile X Syndrome
    Dendritic Spines
    Inborn Genetic Diseases
    Nervous System
    Spine
    Animal Models
    Genotype
    Phenotype

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Kaufmann, W. E., & Moser, H. W. (2000). Dendritic anomalies in disorders associated with mental retardation. Cerebral Cortex, 10(10), 981-991.

    Dendritic anomalies in disorders associated with mental retardation. / Kaufmann, Walter E.; Moser, Hugo W.

    In: Cerebral Cortex, Vol. 10, No. 10, 2000, p. 981-991.

    Research output: Contribution to journalArticle

    Kaufmann, WE & Moser, HW 2000, 'Dendritic anomalies in disorders associated with mental retardation', Cerebral Cortex, vol. 10, no. 10, pp. 981-991.
    Kaufmann, Walter E. ; Moser, Hugo W. / Dendritic anomalies in disorders associated with mental retardation. In: Cerebral Cortex. 2000 ; Vol. 10, No. 10. pp. 981-991.
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