Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

Anupa R. Menjoge, Rangaramanujam M. Kannan, Donald A. Tomalia

Research output: Contribution to journalReview articlepeer-review

Abstract

Dendrimers are members of a versatile, fourth new class of polymer architecture (i.e. dendritic polymers after traditional linear, crosslinked and branched types) [1]. Typically, dendrimers are used as well-defined scaffolding or nanocontainers to conjugate, complex or encapsulate therapeutic drugs or imaging moieties. As a delivery vector, the dendrimer conjugate linker or spacer chemistry plays a crucial part in determining optimum drug delivery to disease sites by conserving active drug efficacy while influencing appropriate release patterns. This review focuses on several crucial issues related to those dendrimer features, namely the role of dendrimers as nanoscaffolding and nanocontainers, crucial principles that might be invoked for improving dendrimer cytotoxicity properties, understanding dendrimer cellular transport mechanisms and the exciting role of dendrimers as high-contrast MRI imaging agents. The review concludes with a brief survey of translational efforts from research and development phases to clinical trials that are actively emerging.

Original languageEnglish (US)
Pages (from-to)171-185
Number of pages15
JournalDrug Discovery Today
Volume15
Issue number5-6
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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