Demyelination and remyelination after spinal cord injury

John W. McDonald, Visar Belegu

Research output: Contribution to journalArticle

Abstract

Since the discovery in the 1960s that remyelination can occur in the damaged central nervous system (CNS) (Bunge et al. 1961), there has been much progress in understanding the cellular and molecular biology of oligodendroglia and the factors that regulate their propagation, migration, differentiation, maturation, and ability to myelinate nerve axons. More recently, greater understanding of disease states and the role of oligodendrocytes in remyelination have sparked tremendous interest in this once obscure field. Although the explosion of information is being hampered by adherence to commonly held beliefs based on empirical evidence, novel molecular and cellular tools are allowing scientists to address age-old assumptions. It is now recognized that, as well as promoting salutatory conduction along axons, oligodendroglia are important near-term clinical targets for restoring function after CNS injury, particularly spinal cord injury. Thus, remyelination appears to be one of the most feasible restoration strategies. This review focuses on concepts that are important for developing strategies of repair. The brightest young scientists will be attracted into this exciting field by its near-term potential for human application.

Original languageEnglish (US)
Pages (from-to)345-359
Number of pages15
JournalJournal of Neurotrauma
Volume23
Issue number3-4
DOIs
StatePublished - Mar 2006

Fingerprint

Oligodendroglia
Demyelinating Diseases
Spinal Cord Injuries
Axons
Central Nervous System
Nervous System Trauma
Explosions
Cell Biology
Molecular Biology

Keywords

  • Activity dependence
  • Oligodendrocytes
  • Progenitors
  • Remyelination
  • Spinal cord injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Demyelination and remyelination after spinal cord injury. / McDonald, John W.; Belegu, Visar.

In: Journal of Neurotrauma, Vol. 23, No. 3-4, 03.2006, p. 345-359.

Research output: Contribution to journalArticle

McDonald, John W. ; Belegu, Visar. / Demyelination and remyelination after spinal cord injury. In: Journal of Neurotrauma. 2006 ; Vol. 23, No. 3-4. pp. 345-359.
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