Demonstration that the temporary sequestering of adventitious iron accounts for the inhibition of microsomal lipid peroxidation by bleomycin A2

M. A. Trush

Research output: Contribution to journalArticlepeer-review

Abstract

One of the manifestations of the interaction of bleomycin with the microsomal mixed-function oxidase system is an inhibition of NAPDH-dependent, reactive oxygen-mediated lipid peroxidation. The results of this investigation demonstrate that this effect by bleomycin can be attributed to the sequestering of adventitious iron. However, as a result of the microsome-catalyzed, iron-facilitated activation of bleomycin and the concomitant spontaneous decay of the activated bleomycin intermediate, iron can apparently no longer be bound by the bleomycin molecule; consequently, the inhibition of microsomal lipid peroxidation by bleomycin is only temporary.

Original languageEnglish (US)
Pages (from-to)21-31
Number of pages11
JournalResearch communications in chemical pathology and pharmacology
Volume37
Issue number1
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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