Demonstration of Papillomavirus Capsid Antigen in Human Conjunctival Neoplasia

Jan M. McDonnell, Peter J McDonnell, Phoebe Mounts, Tzyy Choou Wu, W. Richard Green

Research output: Contribution to journalArticle

Abstract

To investigate the association of human papillomavirus with conjunctival neoplasia, we identified 50 resected papillomas from 47 patients. Papillomas were composed of papillary or, less commonly, flat proliferations of predominantly nonkeratinizing squamous epithelium with admixed goblet cells. Koilocytosis was focally present in 30 tumors (60%). Atypia that ranged from mild to severe was present in ten lesions (20%). In addition, we examined specimens of conjunctival dysplasia or carcinoma from 61 patients. The lesions were predominantly flat proliferations of atypical epithelial cells. Twenty biopsies performed for suspected sarcoidosis were used as controls. Papillomavirus capsid antigen was demonstrated using an immunoperoxidase technique in nuclei of mature superficial epithelial cells of 23 papillomas (46%) and five dysplasias or carcinomas (8.2%) but not in the control biopsy specimens. These results suggest that papillomavirus may play a role in the etiology of conjunctival papilloma, dysplasia, and carcinoma.

Original languageEnglish (US)
Pages (from-to)1801-1805
Number of pages5
JournalArchives of Ophthalmology
Volume104
Issue number12
DOIs
StatePublished - 1986

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Capsid
Papilloma
Antigens
Carcinoma
Neoplasms
Epithelial Cells
Biopsy
Goblet Cells
Sarcoidosis
Immunoenzyme Techniques
Epithelium

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Demonstration of Papillomavirus Capsid Antigen in Human Conjunctival Neoplasia. / McDonnell, Jan M.; McDonnell, Peter J; Mounts, Phoebe; Wu, Tzyy Choou; Green, W. Richard.

In: Archives of Ophthalmology, Vol. 104, No. 12, 1986, p. 1801-1805.

Research output: Contribution to journalArticle

McDonnell, Jan M. ; McDonnell, Peter J ; Mounts, Phoebe ; Wu, Tzyy Choou ; Green, W. Richard. / Demonstration of Papillomavirus Capsid Antigen in Human Conjunctival Neoplasia. In: Archives of Ophthalmology. 1986 ; Vol. 104, No. 12. pp. 1801-1805.
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