Demonstration of motor imagery movement and phantom movement-related neuronal activity in human thalamus

William S Anderson, Nirit Weiss, Herman Christopher Lawson, Shinji Ohara, Lance Rowland, Frederick Lenz

Research output: Contribution to journalArticle

Abstract

Functional imaging studies show that motor imagery activates multiple structures in the human forebrain. We now show that phantom movements in an amputee and imagined movements in intact individuals elicit responses from neurons in several human thalamic nuclei. These include the somatic sensory nucleus receiving input from the periphery (ventral caudal), and the motor nuclei receiving input from the cerebellum [ventral intermediate (Vim)] and the basal ganglia [ventral oral posterior (Vop)]. Seven neurons in the amputee showed phantom movement-related activity (three Vim, two Vop, and two ventral caudal). In addition, seven neurons in a group of three controls showed motor imagery-related activity (four Vim and three Vop). These studies were performed during single neuron recording sessions in patients undergoing therapeutic treatment of phantom pain, tremor, and chronic pain conditions by thalamic stimulation. The activity of neurons in these sensory and motor nuclei, respectively, may encode the expected sensory consequences and the dynamics of planned movements.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalNeuroReport
Volume22
Issue number2
DOIs
StatePublished - Jan 26 2011

Fingerprint

Imagery (Psychotherapy)
Thalamus
Human Activities
Neurons
Amputees
Phantom Limb
Thalamic Nuclei
Motor Neurons
Tremor
Sensory Receptor Cells
Prosencephalon
Basal Ganglia
Chronic Pain
Cerebellum
Control Groups
Therapeutics

Keywords

  • Electrophysiology
  • Motor control
  • Neuroanatomy
  • Neurophysiology
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Demonstration of motor imagery movement and phantom movement-related neuronal activity in human thalamus. / Anderson, William S; Weiss, Nirit; Lawson, Herman Christopher; Ohara, Shinji; Rowland, Lance; Lenz, Frederick.

In: NeuroReport, Vol. 22, No. 2, 26.01.2011, p. 88-92.

Research output: Contribution to journalArticle

Anderson, William S ; Weiss, Nirit ; Lawson, Herman Christopher ; Ohara, Shinji ; Rowland, Lance ; Lenz, Frederick. / Demonstration of motor imagery movement and phantom movement-related neuronal activity in human thalamus. In: NeuroReport. 2011 ; Vol. 22, No. 2. pp. 88-92.
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