TY - JOUR
T1 - Demonstration of Angle Widening Using EyeCam After Laser Peripheral Iridotomy in Eyes With Angle Closure
AU - Perera, Shamira A.
AU - Quek, Desmond T.
AU - Baskaran, Mani
AU - Tun, Tin A.
AU - Kumar, Rajesh S.
AU - Friedman, David S.
AU - Aung, Tin
N1 - Funding Information:
The study was supported by grants from Singapore National Eye Centre , Singhealth Foundation , and National Medical Research Council . Dr T Aung has received travel support and honoraria from Clarity Medical Systems. Drs Perera and Quek contributed equally to this study. Involved in design of the study (T.A., S.A.P.); conduct of the study (S.A.P., T.A., T.A.T., R.S.K., M.B.); collection (S.A.P., T.A.T., R.S.K., M.B., T.A.), management (T.A., S.A.P.), analysis (M.B., S.A.P., T.A., R.S.K.), and interpretation of the data (T.A., R.S.K., M.B., S.A.P., D.S.F.); and preparation, review, and approval of manuscript (S.A.P., M.B., D.T.Q., R.S.K., T.A., D.S.F.). Informed consent for this research was obtained from all participants, and the study had the approval of the Institutional Review Board of the Singapore Eye Research Institute and adhered to the tenets of the Declaration of Helsinki.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/6
Y1 - 2010/6
N2 - Purpose: To evaluate EyeCam in detecting changes in angle configuration after laser peripheral iridotomy (LPI) in comparison to gonioscopy, the reference standard. Design: Prospective comparative study. Methods: Twenty-four subjects (24 eyes) with primary angle-closure glaucoma (PACG) were recruited. Gonioscopy and EyeCam (Clarity Medical Systems) imaging of all 4 angle quadrants were performed, before and 2 weeks after LPI. Images were graded according to angle structures visible by an observer masked to clinical data or the status of LPI, and were performed in a random order. Angle closure in a quadrant was defined as the inability to visualize the posterior trabecular meshwork. We determined the number of quadrants with closed angles and the mean number of clock hours of angle closure before and after LPI in comparison to gonioscopy. Results: Using EyeCam, all 24 eyes showed at least 1 quadrant of angle widening after LPI. The mean number of clock hours of angle closure decreased significantly, from 8.15 ± 3.47 clock hours before LPI to 1.75 ± 2.27 clock hours after LPI (P < .0001, Wilcoxon signed rank test). Overall, gonioscopy showed 1.0 ± 1.41 (95% CI, 0.43-1.57) quadrants opening from closed to open after LPI compared to 2.0 ± 1.28 (95% CI, 1.49-2.51, P = .009) quadrants with EyeCam. Intra-observer reproducibility of grading the extent of angle closure in clock hours in EyeCam images was moderate to good (intraclass correlation coefficient 0.831). Conclusions: EyeCam may be used to document changes in angle configuration after LPI in eyes with PACG.
AB - Purpose: To evaluate EyeCam in detecting changes in angle configuration after laser peripheral iridotomy (LPI) in comparison to gonioscopy, the reference standard. Design: Prospective comparative study. Methods: Twenty-four subjects (24 eyes) with primary angle-closure glaucoma (PACG) were recruited. Gonioscopy and EyeCam (Clarity Medical Systems) imaging of all 4 angle quadrants were performed, before and 2 weeks after LPI. Images were graded according to angle structures visible by an observer masked to clinical data or the status of LPI, and were performed in a random order. Angle closure in a quadrant was defined as the inability to visualize the posterior trabecular meshwork. We determined the number of quadrants with closed angles and the mean number of clock hours of angle closure before and after LPI in comparison to gonioscopy. Results: Using EyeCam, all 24 eyes showed at least 1 quadrant of angle widening after LPI. The mean number of clock hours of angle closure decreased significantly, from 8.15 ± 3.47 clock hours before LPI to 1.75 ± 2.27 clock hours after LPI (P < .0001, Wilcoxon signed rank test). Overall, gonioscopy showed 1.0 ± 1.41 (95% CI, 0.43-1.57) quadrants opening from closed to open after LPI compared to 2.0 ± 1.28 (95% CI, 1.49-2.51, P = .009) quadrants with EyeCam. Intra-observer reproducibility of grading the extent of angle closure in clock hours in EyeCam images was moderate to good (intraclass correlation coefficient 0.831). Conclusions: EyeCam may be used to document changes in angle configuration after LPI in eyes with PACG.
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U2 - 10.1016/j.ajo.2010.01.013
DO - 10.1016/j.ajo.2010.01.013
M3 - Article
C2 - 20417499
AN - SCOPUS:77952550513
SN - 0002-9394
VL - 149
SP - 903
EP - 907
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -